1401681-62-6

Basic information

• Product Name: 5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester
• Synonyms: 5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester
• CAS NO: 1401681-62-6
• Molecular Weight: 328.3
• Mol File: 1401681-62-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester(1401681-62-6)
• EPA Substance Registry System: 5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester(1401681-62-6)

Safety Data

• Hazardous Substances Data: 1401681-62-6(Hazardous Substances Data)

Upstream product

• 321-12-0 2-fluoro-5-methyl-benzoic acid 
• 2967-93-3 2-fluoro-5-methyl benzoic acid methyl ester 
• 118-92-3 anthranilic acid 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 709-45-5 2-fluoro-5-bromomethyl benzoic acid methyl ester 

Downstream Products

• 1399119-66-4 5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid 

Relevant articles and documents

Discovery of quinazoline-2,4(1: H,3 H)-dione derivatives as novel PARP-1/2 inhibitors: Design, synthesis and their antitumor activity

Novel quinazoline-2,4(1H,3H)-dione derivatives bearing a 3-amino pyrrolidine moiety were designed and synthesized as PARP-1/2 inhibitors. Structure-activity relationships were examined which revealed a number of potent PARP-1/2 inhibitors with moderate se

3-amino nafoxidine-containing quinazoline ketone PARP (Poly Adenosine Diphosphate Ribose Polymerase)-1/2 inhibitor as well as preparation method, medicinal composition and application thereof

The invention discloses a novel 3-amino nafoxidine-containing quinazoline-2,4(1H, 3H)-diketone PARP-1/2 (Poly Adenosine Diphosphate Ribose Polymerase) inhibitor as well as a preparation method, a medicinal composition and application thereof. Specifically, the invention relates to a 3-amino nafoxidine-containing quinazoline-2,4(1H, 3H)-diketone derivative and a medicinal salt thereof of formula (I) as shown in the specification, a preparation method thereof, a composition with one or more such compounds, preparation of the compounds, and application thereof in preparing medicines for preventing and/or treating PARP-1/2 related diseases.

Quinazolinone PARP-1 inhibitors, medicinal composition containing inhibitors, and antitumor use of inhibitors

The invention discloses quinazolinyl-2,4(1H,3H)-dione PARP-1 inhibitors, and a preparation method, a medicinal composition and a use thereof. The invention concretely relates to quinazolinyl-2,4(1H,3H)-dione derivatives represented by general formula I, a medicinal salt and a preparation method thereof, a composition containing one or more of the compounds, and a use of the compounds in the preparation of tumor prevention and/or treatment medicines.