1402043-08-6

Basic information

• Product Name: N-(4-bromo-2-(chloromethyl)phenyl)-4-methylbenzenesulfonamide
• Synonyms: N-(4-bromo-2-(chloromethyl)phenyl)-4-methylbenzenesulfonamide
• CAS NO: 1402043-08-6
• Molecular Weight: 374.686
• Mol File: 1402043-08-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(4-bromo-2-(chloromethyl)phenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromo-2-(chloromethyl)phenyl)-4-methylbenzenesulfonamide(1402043-08-6)
• EPA Substance Registry System: N-(4-bromo-2-(chloromethyl)phenyl)-4-methylbenzenesulfonamide(1402043-08-6)

Safety Data

• Hazardous Substances Data: 1402043-08-6(Hazardous Substances Data)

Upstream product

• 20712-12-3 (2-amino-5-bromophenyl)methanol 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 329281-02-9 N-(4-bromo-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide 

Downstream Products

• 89671-76-1 (5-bromo-1H-indol-2-yl)(phenyl)methanone 
• 16732-70-0 ethyl 5-bromoindolecarboxylate 

Relevant articles and documents

A [4+3] Cycloaddition Reaction of Aza-ortho-quinone Methides with C,N-Cyclic Azomethine Imines for Synthesis of 1,2,4-Triazepines

The base-induced formal [4+3] cycloaddition reaction of C,N-cyclic azomethine imines with aza-ortho-quinone methides, generated in situ, is reported. This protocol provided an efficient method for the synthesis of biologically important 1,2,4-triazepine derivatives, with a wide substrate scope and excellent functional-group tolerance, and it gives moderate to excellent yields under mild conditions. Several of the derivatives exhibited in vitro antitumor activities against the A2780 cell line in a screening of the cancer cell lines HCT-116, H2228, and A2780 by an MTT assay.

Pd(II)-catalyzed enantioselective intramolecular oxidative amination utilizing (+)-camphorsulfonic acid

An enantioselective Pd(II)-catalyzed intramolecular oxidative amination reaction was developed utilizing the commercially available chiral X-type ligand (1S)-(+)-camphorsulfonic acid. The Wacker-type cyclization produced chiral indoline products with enantioselectivies up to 45% ee. Electronic structure calculations employing density functional theory support a trans-aminopalladation mechanism.