1402070-27-2Relevant articles and documents
Cephalosporin-3'-diazeniumdiolates: Targeted NO-donor prodrugs for dispersing bacterial biofilms
Barraud, Nicolas,Kardak, Bharat G.,Yepuri, Nageshwar R.,Howlin, Robert P.,Webb, Jeremy S.,Faust, Saul N.,Kjelleberg, Staffan,Rice, Scott A.,Kelso, Michael J.
, p. 9057 - 9060 (2012)
Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication. Copyright
REGULATION OF NITRIC OXIDE RELEASE AND BIOFILM DEVELOPMENT
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Page/Page column 52, (2012/12/13)
Regulation of nitric oxide release and biofilm development Abstract The present invention relates generally to methods and compounds for regulating the release of nitric oxide in the vicinity of biofilm-forming microorganisms to regulate programmed cell death in the microorganisms and thereby promote dispersal of microorganism from biofilms and/or inhibit biofilm formation or development. More particularly, the invention relates to the use of compounds to provide spatial and temporal control over nitric oxide release.