1402150-30-4

Basic information

• Product Name: 2-((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol oxalate
• Synonyms: 2-((3aS,4R,6S,6aR)-4-amino-tetrahydro-2,2-dimethyl-3aH-cyclopenta[d][1,3]dioxol-6-yloxy)ethanol oxalic acid salt;2-[[(3aS,4R,6S,6aR)-4-Aminotetrahydro-2,2-dimethyl-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol Oxalate
• CAS NO: 1402150-30-4
• Molecular Formula: C₂H₂O₄*C₁₀H₁₉NO₄
• Molecular Weight: 307.29704
• Mol File: 1402150-30-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol oxalate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol oxalate(1402150-30-4)
• EPA Substance Registry System: 2-((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol oxalate(1402150-30-4)

Safety Data

• Hazardous Substances Data: 1402150-30-4(Hazardous Substances Data)

Usage

Description

2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol oxalate is a complex organic compound characterized by its unique molecular structure. It is a derivative of tetrahydro-3aH-cyclopenta[d][1,3]dioxol, featuring an amino group and a hydroxyethyloxy group attached to its core structure. The compound's stereochemistry is defined by the (3aR,4S,6R,6aS) configuration, which plays a crucial role in its potential applications and interactions.

Uses

Used in Pharmaceutical Industry:
2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol oxalate is used as an intermediate in the preparation of orally active reversible P2Y12 receptor antagonists. These antagonists are essential for the prevention of thrombosis, a medical condition characterized by the formation of blood clots within the circulatory system. The compound's unique structure allows it to interact with the P2Y12 receptor, blocking its activation and thus preventing platelet aggregation and clot formation.
The development of this compound as an intermediate in the synthesis of P2Y12 receptor antagonists highlights its potential in the pharmaceutical industry, particularly in the treatment and prevention of thrombotic disorders. Its specific stereochemistry and functional groups enable it to serve as a key building block in the synthesis of these therapeutic agents, contributing to their efficacy and safety profiles.

Upstream product

• 274693-55-9 [3aR-(3aα,4α,6α,6aα)]-2-[[6-amino-2,2-dimethyl tetrahydro-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol 
• 144-62-7 oxalic acid 
• 274693-54-8 benzyl 6-(2-hydroxyethoxy)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ylcarbamate 
• 866551-95-3 ethyl 2-(6-(benzyloxycarbonylamino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy) acetate 
• 274693-53-7 [3aS-(3aα,4α,6α,6aα)]-(tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl)carbamic acid phenylmethyl ester 
• 155899-66-4 (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol 

Downstream Products

• 376608-74-1 2-[((3aR,4S,6R,6aS)-6-[[5-amino-6-chloro-2-(propylsulfanyl)-4-pyrimidinyl]amino]-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy]-1-ethanol 
• 274693-27-5 ticagrelor 
• 1402150-32-6 (1S 2S,3R,5S)-3-[(5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol 
• 1354945-69-9 9-[(1’R,2’S,3’S,4’S)-2’,3’-dihydroxyl-4'-hydroxyethoxycyclopenta-1'-yl]-9H-2-thiopropyl-6-chloro-8-azepine 

Relevant articles and documents

NEW INTERMEDIATES AND PROCESSES FOR PREPARING TICAGRELOR

The present invention is related to new intermediates and processes for preparing Ticagrelor disclosed in this patent application.