1402451-98-2

Basic information

• Product Name: C₂₁H₂₂N₆O₃S
• CAS NO: 1402451-98-2
• Molecular Weight: 438.51
• Mol File: 1402451-98-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₂N₆O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₂N₆O₃S(1402451-98-2)
• EPA Substance Registry System: C₂₁H₂₂N₆O₃S(1402451-98-2)

Safety Data

• Hazardous Substances Data: 1402451-98-2(Hazardous Substances Data)

Upstream product

• 98-18-0 m-aminobenzenesulfonamide 
• 4431-64-5 3-guanidinobenzenesulfonamide 
• 280-07-9 3-oxa-8-aza-bicyclo[3.2.1]octane 
• 1402452-02-1 C₁₅H₁₂ClN₅O₂S 

Relevant articles and documents

Identification of pyrimidine derivatives as hSMG-1 inhibitors

hSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment. From our screening efforts, we have identified pyrimidine derivatives as hSMG-1 kinase inhibitors. We report structure-based optimization of this pan-kinase scaffold to improve its biochemical profile and overall kinome selectivity, including mTOR and CDK, to generate the first reported selective hSMG-1 tool compound.