140373-03-1

Basic information

• Product Name: Benzoic acid, 2-fluoro-4-(2-propynylamino)-, 1,1-dimethylethyl ester
• CAS NO: 140373-03-1
• Molecular Formula: C14H16FNO2
• Molecular Weight: 249.285
• Mol File: 140373-03-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-fluoro-4-(2-propynylamino)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-fluoro-4-(2-propynylamino)-, 1,1-dimethylethyl ester(140373-03-1)
• EPA Substance Registry System: Benzoic acid, 2-fluoro-4-(2-propynylamino)-, 1,1-dimethylethyl ester(140373-03-1)

Safety Data

• Hazardous Substances Data: 140373-03-1(Hazardous Substances Data)

Upstream product

• 106-96-7 propargyl bromide 
• 140373-77-9 tert-butyl 2-fluoro-4-aminobenzoate 

Downstream Products

• 173951-98-9 2-Fluoro-4-prop-2-ynylamino-benzoic acid 
• 153538-14-8 tert-butyl 4-[[(3-{[(2,2-dimethylpropanoyl)oxy]methyl}-2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]-2-fluorobenzoate 
• 161878-88-2 (S)-4-((S)-1-tert-Butoxycarbonyl-ethylcarbamoyl)-2-{2-fluoro-4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyric acid tert-butyl ester 
• 145789-04-4 (R)-2-((S)-4-tert-Butoxycarbonyl-4-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-fluoro-benzoylamino}-butyrylamino)-pentanedioic acid di-tert-butyl ester 
• 145789-03-3 (R)-2-((S)-4-tert-Butoxycarbonyl-4-{2-fluoro-4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyrylamino)-pentanedioic acid di-tert-butyl ester 
• 173952-23-3 Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester 
• 173952-25-5 2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N-(3-nitro-benzyl)-benzamide 
• 173952-27-7 4-[(2-Chloromethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-fluoro-N-(3-nitro-benzyl)-benzamide 
• 173952-01-7 1-<amino>methyl>-3-nitrobenzene 
• 172793-47-4 tert-butyl 4--N-prop-2-ynylamino>-2-fluorobenzoate 
• 172793-46-3 tert-butyl 4--N-prop-2-ynylamino>-2-fluorobenzoate 

Relevant articles and documents

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Quinazolines of the formula: STR1 wherein R1 -R8 are defined as in the specification, or a pharmaceutically acceptable salt, ester or amide thereof areof therapeutic value, particularly in the treatment of cancer.

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The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula: STR1 wherein R1 includes hydrogen, amino and alkyl or alkoxy each of up to 4 carbon atoms; R2 includes hydrogen, alkyl, hydroxyalkyl and halogenoalkyl each of up to 4 carbon atoms; R3 is hydrogen or alkyl or up to 3 carbon atoms; Ar is phenylene or heterocyclene; L is a group of the formula --CO.NH--, --NH.CO--, --CO.NR4 --, --NR4.CO--, --CH=CH-- or --CO.O--, wherein R4 is alkyl of up to 4 carbon atoms; and Y is a branched alkyl group bearing substituents Y2 and Y3 the definition of each independently including hydroxy, cyano, aryl and heteroaryl, and the definition of Y3 also optionally including sulpho, N-phenylsulphonylcarbamoyl and 5-tetrazolyl; or a pharmaceutically-acceptable salt thereof.