1403962-48-0Relevant articles and documents
Design, synthesis, and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold
Choi, Won-Kyoung,El-Gamal, Mohammed I.,Choi, Hong Seok,Hong, Jun Hee,Baek, Daejin,Choi, Kihang,Oh, Chang-Hyun
, p. 2991 - 2998 (2012/10/30)
A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3- (trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.