1405126-79-5

Basic information

• Product Name: N-(4-((2S,3R)-3-amino-2-methyl-1-piperidinyl)-3-pyridinyl)-2-(3-fluoro-2-pyridinyl)imidazo[,5-b]pyridazin-7-amine
• Synonyms: N-(4-((2S,3R)-3-amino-2-methyl-1-piperidinyl)-3-pyridinyl)-2-(3-fluoro-2-pyridinyl)imidazo[,5-b]pyridazin-7-amine
• CAS NO: 1405126-79-5
• Molecular Weight: 435.479
• Mol File: 1405126-79-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-((2S,3R)-3-amino-2-methyl-1-piperidinyl)-3-pyridinyl)-2-(3-fluoro-2-pyridinyl)imidazo[,5-b]pyridazin-7-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-((2S,3R)-3-amino-2-methyl-1-piperidinyl)-3-pyridinyl)-2-(3-fluoro-2-pyridinyl)imidazo[,5-b]pyridazin-7-amine(1405126-79-5)
• EPA Substance Registry System: N-(4-((2S,3R)-3-amino-2-methyl-1-piperidinyl)-3-pyridinyl)-2-(3-fluoro-2-pyridinyl)imidazo[,5-b]pyridazin-7-amine(1405126-79-5)

Safety Data

• Hazardous Substances Data: 1405126-79-5(Hazardous Substances Data)

Upstream product

• 1405128-97-3 tert-butyl ((2S,3R)-1-(3-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)pyridin-4-yl)-2-methylpiperidin-3-yl)carbamate 
• 1405127-64-1 3-(azidomethyl)-6-(2,6-difluorophenyl)pyridazine 
• 1405127-63-0 3-(chloromethyl)-6-(2,6-difluorophenyl)pyridazine 
• 1405127-62-9 3-(2,6-difluorophenyl)-6-methylpyridazine 
• 1121-79-5 3-chloro-6-methylpyridazine 
• 1618-47-9 3-iodo-6-methylpyridazine 

Relevant articles and documents

BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS

The invention relates to bicyclic compounds of formulas I and I', and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.