14065-23-7

Basic information

• Product Name: 1-methoxy-2-[(4-methoxyphenyl)thio]benzene
• Synonyms: 1-methoxy-2-[(4-methoxyphenyl)thio]benzene
• CAS NO: 14065-23-7
• Molecular Weight: 246.33
• Mol File: 14065-23-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1-methoxy-2-[(4-methoxyphenyl)thio]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methoxy-2-[(4-methoxyphenyl)thio]benzene(14065-23-7)
• EPA Substance Registry System: 1-methoxy-2-[(4-methoxyphenyl)thio]benzene(14065-23-7)

Safety Data

• Hazardous Substances Data: 14065-23-7(Hazardous Substances Data)

Upstream product

• 696-63-9 4-Methoxybenzenethiol 
• 529-28-2 4-iodoanisol 
• 100-66-3 methoxybenzene 
• 7217-59-6 2-Methoxybenzenethiol 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 578-57-4 2-bromoanisole 
• 60787-31-7 S-(4-methoxyphenyl) ethanethioate 
• 14065-14-6 2,4'-Dimethoxy-5-nitro-diphenylsulfid 
• 14065-09-9 4'-Methoxy-2-hydroxy-5-nitro-diphenylsulfid 
• 25784-84-3 1-[(4-methoxyphenyl)thio]acetone 
• 79161-48-1 copper(I) 4-methoxybenzenethiolate 
• 696-62-8 para-iodoanisole 

Downstream Products

• 24197-29-3 1-methoxy-2-((4-methoxyphenyl)sulfonyl)benzene 
• 57154-52-6 (2-acetoxy-phenyl)-(4-acetoxy-phenyl)-sulfone 
• 5397-34-2 2,4'-dihydroxydiphenyl sulfone 

Relevant articles and documents

A general palladium-catalysed synthesis of aromatic and heteroaromatic thioethers

Thioethers can be efficiently prepared via palladium-catalysed cross-coupling of arene- or heteroarene thiols with arene- or heteroarene iodides. A simple, cheap and robust catalytic system is described that couples a broad range of electron-deficient as well as electron-rich substrates in high yield.

Thiol Activation toward Selective Thiolation of Aromatic C-H Bond

Direct C-S bond coupling is an attractive way to construct aryl sulfur ether, a building block for a variety of biological active molecules. Herein, we disclose an effective model for regioselective thiolation of the aromatic C-H bond by thiol activation instead of arene activation. Strikingly, this method has been applied into anisole derivatives that are not available in the arene activation approach to forge a single thioether isomer with high reactivity.

Mild synthesis method for diaryl sulfide

The invention provides a mild synthesis method for diaryl sulfide. The method comprises the following steps: sulfonyl chloride used as a reaction substrate is reduced by triphenylphosphine to form a disulfide intermediate; and the disulfide intermediate and boric acid undergo a coupling reaction for 2-4 h under the catalysis of a copper-phenanthroline ligand compound with potassium carbonate as abase in order to prepare a sulfide derivative in a high yield. In the present invention, the sulfide derivative is simply and efficiently synthesized from sulfonyl chloride and boric acid through copper catalysis and triphenylphosphine reduction, and the sulfur atom of the product is derived from the sulfonyl chloride. Compared with thiophenol, the raw material sulfonyl chloride has the advantagesof no unpleasant odor, greenness, and easy availability. The aryl boronic acid has stable properties, is convenient to operate, can be easily obtained, and has a low price. The method has the advantages of simplicity in reaction operation, high product yield, and avoiding of the disadvantages of air pollution, high temperature and too long reaction time.