1408238-41-4 Usage
Description
Dabigatran Impurity 9, also known as Des-(3-(Pyridin-2-ylamino)propanoate) Dabigatran Ethyl Ester, is an intermediate compound in the synthesis of A611088, a degradation product of Dabigatran (D100090). Dabigatran is a nonpeptide, direct thrombin inhibitor and an antithrombotic drug, which plays a crucial role in the prevention and treatment of various thrombotic disorders.
Uses
Used in Pharmaceutical Industry:
Dabigatran Impurity 9 is used as an intermediate compound for the synthesis of A611088, which is a degradation product of Dabigatran (D100090). This impurity plays a significant role in the development and production of antithrombotic drugs, contributing to the prevention and treatment of thrombotic disorders.
Used in Research and Development:
Dabigatran Impurity 9 is utilized in research and development for the study of its chemical properties, synthesis pathways, and potential applications in the pharmaceutical industry. This impurity can provide valuable insights into the development of new antithrombotic drugs and the improvement of existing ones.
Used in Quality Control and Regulatory Compliance:
Dabigatran Impurity 9 is employed in quality control processes to ensure the purity and safety of Dabigatran and its related compounds. It is also used in regulatory compliance to meet the standards and guidelines set by various regulatory authorities for the approval and marketing of antithrombotic drugs.
Used in Drug Synthesis and Manufacturing:
Dabigatran Impurity 9 is used in the synthesis and manufacturing of Dabigatran and its related compounds. It serves as a crucial intermediate in the production process, ensuring the efficient and cost-effective production of antithrombotic drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 1408238-41-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,0,8,2,3 and 8 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1408238-41:
(9*1)+(8*4)+(7*0)+(6*8)+(5*2)+(4*3)+(3*8)+(2*4)+(1*1)=144
144 % 10 = 4
So 1408238-41-4 is a valid CAS Registry Number.
1408238-41-4Relevant articles and documents
Preparation method of anticoagulant drug dabigatran etexilate and analogues thereof
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Paragraph 0060; 0062; 0067-0068, (2020/05/01)
The invention discloses a preparation method of an anticoagulant drug dabigatran etexilate and analogues thereof. The preparation method comprises the following steps: 3-[(3-amino-4-methylaminobenzoyl)pyridin-2-ylamino]propionic acid ethyl ester (DGM1) and isopropyl 2-(4-cyanophenylamino)acetate (DGM2) which are taken as reaction initial raw materials undergo a docking reaction under the action ofan alkali reagent and a condensing agent to prepare an intermediate DG1; the intermediate DG1 reacts in an alcohol solvent to produce imino ester, and acid catalysis and ammonia reaction are carriedout to prepare a formamidine compound; an intermediate DG2 reacts with n-hexyl chloroformate under the action of the alkali reagent to remove one molecule of water and form an amido bond in order to obtain dabigatran etexilate; and the dabigatran etexilate analogues DG-D1 to DG-D4 are prepared from the dabigatran etexilate and its intermediate DG2. The preparation method of the dabigatran etexilate and analogues thereof has the advantages of short and feasible synthesis route, simplicity in operation, high product yield is high, and suitableness for large-scale industrial production.
