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141-01-5

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141-01-5 Usage

Uses

Different sources of media describe the Uses of 141-01-5 differently. You can refer to the following data:
1. Iron(II) Fumarate is a a chemical used in the treatment of iron deficiency. More commonly used for this treatment is Ferrous Sulfate however Iron(II) Fumarate does maintain similar absorption profiles.
2. Ferrous fumarate is available as a syrup and may be useful in small children for the treatment and prophylaxis of iron deficiency.
3. Ferrous Fumarate is a reddish orange to red-brown powder that is a source of iron. it has high bioavailability and can be used in foods where the red color can be masked. it contains approximately 33% iron. it is used as a dietary supplement in breakfast cereals, poultry stuffing, enriched flour, and instant drinks.
4. Iron(II) fumarate is used as dietary Supplement, nutrient, iron source in foods and pharmaceuticals, as animal feed additive and in infant formulas.

Description

Ferrous fumarate is the ferrous salt form of fumarate. One of its most important applications is being used as iron supplements for the treatment of iron deficiency and anemia. It has been demonstrated that application of ferrous sulfate drops or a single daily dose of microencapsulated ferrous fumarate sprinkles plus ascorbic acid both result in successful treatment of anemia without remarkable side effects. However, recent studies have also shown that compared to other iron supplements, ferrous fumarate has a highest rate of inducing adverse reactions such as erosive mucosal injury in the gastrointestinal tract as well as nausea, vomiting and epigastric discomfort.

Chemical Properties

Different sources of media describe the Chemical Properties of 141-01-5 differently. You can refer to the following data:
1. brown to reddish-brown powder
2. §184.1307d(a) Ferrous fumarate (iron(II)fumarate, C4H2Fe04) is an odorless, reddish-orange to reddish-brown powder. It may contain soft lumps that produce a yellow streak when crushed. It is prepared by admixing hot solutions of ferrous sulfate and sodium fumarate.

Originator

Toleron,Mallinckrodt Inc.,US,1957

Definition

Anhydrous salt of a combination of ferrous iron and fumaric acid, stable, odorless, substantially tasteless. Reddish-brown, anhydrous powder, contains 33% iron by weight, does not melt at temperatures up to 280C, insoluble in alcohol, very slightly solubl

Manufacturing Process

Sodium carbonate (53.5 pounds of Na2CO3-H2O) was dissolved in water (40 to 45 gallons) and fumaric acid (50 pounds) was added slowly. During the addition the solution was stirred and heated. The resulting solution of sodium fumarate, having a pH of 6.8, was added slowly with mixing to a solution of ferrous sulfate (118 pounds FeSO4-7H2O in 33 gallons of water) having a pH of 3.3, both solutions being maintained at or near boiling temperature during the mixing. The resulting slurry of reddish-brown anhydrous ferrous fumarate was filtered and washed in a centrifuge and dried in a tray drier (15 hours at 110°C). Yield: 63 pounds, 86% of theory. Calculated for FeC4H2O4: Fe, 32.9%. Found: Fe, 32.6%. Only 0.2% of ferric iron (Fe+++) was found.

Therapeutic Function

Hematinic

General Description

Ferrous fumarate is a commonly used inexpensive substitute for other forms of iron, that is employed as a food iron fortificant.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Flammability and Explosibility

Notclassified

Clinical Use

Iron deficiency anaemia

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: dyspnea, nausea or vomiting, somnolence. When heated to decomposition it emits acrid smoke and irritating fumes. See also FUMRIC ACID.

Drug interactions

Potentially hazardous interactions with other drugs Antibacterials: reduced absorption of 4-quinolones and tetracyclines. Dimercaprol: avoid concomitant use. Mycophenolate: may significantly reduce absorption of mycophenolate.

Metabolism

Molecular weight (daltons) 169.9 % Protein binding - % Excreted unchanged in urine - Volume of distribution (L/kg) - Half-life - normal/ESRF (hrs) -

References

Zlotkin, Stanley, et al. "Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods." The American journal of clinical nutrition 74.6 (2001): 791-795.Cancelo-Hidalgo, María Jesús, et al. "Tolerability of different oral iron supplements: a systematic review." Current medical research and opinion 29.4 (2013): 291-303.

Check Digit Verification of cas no

The CAS Registry Mumber 141-01-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 141-01:
(5*1)+(4*4)+(3*1)+(2*0)+(1*1)=25
25 % 10 = 5
So 141-01-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H4O4.Fe/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2

141-01-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (B23956)  Iron(II) fumarate, 94%   

  • 141-01-5

  • 250g

  • 616.0CNY

  • Detail
  • Alfa Aesar

  • (B23956)  Iron(II) fumarate, 94%   

  • 141-01-5

  • 1000g

  • 1037.0CNY

  • Detail
  • Aldrich

  • (F5381)  Iron(II) fumarate  ≥97.0%

  • 141-01-5

  • F5381-500G

  • 900.90CNY

  • Detail

141-01-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Ferrous fumarate

1.2 Other means of identification

Product number -
Other names ferrone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:141-01-5 SDS

141-01-5Upstream product

141-01-5Downstream Products

141-01-5Related news

Microencapsulation for iodine stability in salt fortified with Ferrous fumarate (cas 141-01-5) and potassium iodide09/29/2019

Fortification of salt with both iodine and iron is an attractive approach to simultaneous reduction of anemia and iodine deficiency disorders (IDD), which affect some 2 billion people in the developing world. Unfortunately iodine is unstable under storage conditions found in most developing coun...detailed

Iron Supplementation of Low-Income Infants: A Randomized Clinical Trial of Adherence with Ferrous fumarate (cas 141-01-5) Sprinkles Versus Ferrous Sulfate Drops10/01/2019

To determine whether low-income infants' adherence to nutritional supplementation with ferrous fumarate sprinkles was better than that with ferrous sulfate drops.The study was a randomized clinical trial of healthy 6-month-old infants. Each infant received either a daily packet of sprinkles or a...detailed

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