141036-66-0Relevant articles and documents
Development of a robust immobilized organocatalyst for the redox-neutral mitsunobu reaction
Lai, Junshan,Llanes, Patricia,Mastandrea, Marco M.,Pericàs, Miquel A.,Perulli, Stefania,Zhou, Leijie
, p. 8859 - 8864 (2021/11/23)
A polystyrene-supported version of the Denton catalyst for redox-neutral Mitsunobu reactions, (2-hydroxybenzyl)diphenylphosphine oxide, has been developed and used in catalytic inversion of enantiopure secondary alcohols (21 examples, up to 97% yield and 98% ee) with 2-nitrobenzoic and 2,4-dinitrobenzoic acids. The use in the reaction of alternative pronucleophiles has also been explored (8 successful and 3 unsuccessful examples). The functional resin shows high recyclability (10 cycles, 30 days operation) and can be re-activated by simple treatment with butylamine with further extension of its useful life.
A General Diastereoselective Strategy for Both cis- and trans-2,6-Disubstituted Tetrahydropyrans: Formal Total Synthesis of (+)-Muconin
Srinivas, Beduru,Reddy, D. Srinivas,Mallampudi, N. Arjunreddy,Mohapatra, Debendra K.
, p. 6910 - 6914 (2018/11/02)
A protocol for general diastereoselective tandem dihydroxylation followed by SN2 cyclization was developed for the convenient and efficient synthesis of cis- and trans-2,6-disubstituted tetrahydropyrans from ζ-mesyloxy α,β-unsaturated esters. T
Asymmetric epoxidation of alkenes and benzylic hydroxylation with P450tol monooxygenase from Rhodococcus coprophilus TC-2
Li, Aitao,Wu, Shuke,Adams, Joseph P.,Snajdrova, Radka,Li, Zhi
supporting information, p. 8771 - 8774 (2014/07/22)
P450tol monooxygenase was discovered as a unique and highly enantioselective enzyme for asymmetric epoxidation of some terminal alkenes containing electron-withdrawing groups and benzylic hydroxylation of several ethylbenzenes giving the corresponding useful and valuable products, such as (R)-2- and 3-substituted styrene oxides, (S)-4-substituted styrene oxides, and (S)-benzylic alcohols, in high ee.