141113-42-0

Basic information

• Product Name: 1H-1,2,4-TRIAZOLE, 1-[[(2S)-2-(2,4-DIFLUOROPHENYL)OXIRANYL]METHYL]-
• Synonyms: 1H-1,2,4-TRIAZOLE, 1-[[(2S)-2-(2,4-DIFLUOROPHENYL)OXIRANYL]METHYL]-;Posaconazole inter-6;1-[[(2S)-2-(2,4-Difluorophenyl)oxiranyl]methyl]-1H-1,2,4-triazole;Posaconazole intermediate-6
• CAS NO: 141113-42-0
• Molecular Formula: C₁₁H₉F₂N₃O
• Molecular Weight: 237.208
• Mol File: 141113-42-0.mol
• Article Data: 48

Chemical Properties

• Boiling Point: 370.5 °C at 760 mmHg
• Flash Point: 177.9 °C
• Appearance: /
• Density: 1.46
• CAS DataBase Reference: 1H-1,2,4-TRIAZOLE, 1-[[(2S)-2-(2,4-DIFLUOROPHENYL)OXIRANYL]METHYL]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-TRIAZOLE, 1-[[(2S)-2-(2,4-DIFLUOROPHENYL)OXIRANYL]METHYL]-(141113-42-0)
• EPA Substance Registry System: 1H-1,2,4-TRIAZOLE, 1-[[(2S)-2-(2,4-DIFLUOROPHENYL)OXIRANYL]METHYL]-(141113-42-0)

Safety Data

• Hazardous Substances Data: 141113-42-0(Hazardous Substances Data)

Usage

General Description

1H-1,2,4-triazole, 1-[[2S)-2-(2,4-difluorophenyl)oxiranyl]methyl]- is a chemical compound with potential pharmaceutical applications. It is a triazole derivative with a substituted oxirane ring, and it has a chiral center at the 2-position. 1H-1,2,4-TRIAZOLE, 1-[[(2S)-2-(2,4-DIFLUOROPHENYL)OXIRANYL]METHYL]- is of interest to researchers due to its potential as a drug molecule, particularly in the development of antifungal and antimicrobial agents. The presence of the oxirane group and the difluorophenyl moiety may contribute to its bioactivity and pharmacological properties. Further research and development of this compound may lead to the discovery of novel therapeutics for various medical conditions.

Upstream product

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Downstream Products

• 205435-16-1 1-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]-1-ethyl-1-methylhydrazinium inner salt 
• 118689-07-9 (S)-(+)-2(2,4-Difluorophenyl)-3-(1,2,4-triazol-1-yl)-1,2-propanediol 
• 128063-72-9 2-(2,4-Difluorophenyl)-3-(4-[4-(4-nitrophenyl)piperazin-1-yl]phenoxy)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol 
• 103992-88-7 2-[3-(4-cyanostyryl)-1,2,4-triazol-1-yl]-1-(2,4-difluorophenyl)-1-(1,2,4-triazol-1-yl methyl)ethanol 
• 844879-66-9 1-[3-(4-benzyloxyphenyl)-[(1H)-1,2,4-triazol-1-yl]-2-(2,4-difluorophenyl)]-3-[1,2,4-triazol-1-yl]-propan-2-ol 

Relevant articles and documents

Preparation method of posaconazole intermediate

The invention relates to the technical field of medicine preparation, and especially relates to a preparation method of a posaconazole intermediate. The preparation method comprises the following steps: reacting a compound as shown in a formula II, serving as a raw material, with 1, 2, 4-triazole to obtain a compound as shown in a formula III, and then reacting with air or oxygen under the action of a catalyst 1 to obtain a compound as shown in a formula IV; reacting the compound as shown in the formula IV with dimethyl malonate to obtain a compound as shown in a formula V; reacting the compound shown in the formula V under the action of a reducing agent to obtain a compound shown in a formula VI; and finally, carrying out intramolecular etherification reaction on the compound shown in the formula VI, and carrying out sulfonylation reaction on the obtained product to obtain a target product I. The method has the advantages of cheap and easily available raw materials, mild reaction conditions, few reaction steps, high yield and high purity of the obtained product.

TRIAZOLE DERIVATIVES WITH ANTIFUNGAL ACTIVITY

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, Q2, L1 and n are as defined herein. The compounds have antifungal properties and are useful in the treatment of fungal infections, including infections that are resistant to conventions anti-fungal agents. Q1 is selected from: (Formulae Ia, Ib, Ic, Id, Ie, If, Ig, Ih, Ii, Ij and Ik) wherein * indicates the point of attachment to L1.

Triazole compounds, preparation method and application of triazole compounds in antifungal drugs

The invention discloses a series of novel triazole compounds obtained by coupling a triazole drug skeleton and diversified lipophilic cations through different chains, and also discloses a preparationmethod of the compounds and application of the compound