141210-63-1

Basic information

• Product Name: 3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE
• Synonyms: 3-[(DIMETHYLAMINO)METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE;3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE;(3Z)-3-[(Dimethylamino)methylene]-1,3-dihydro-2H-indol-2-one;(3Z)-3-(dimethylaminomethylene)-2-indolinone;(3Z)-3-(dimethylaminomethylene)indolin-2-one;(3Z)-3-(dimethylaminomethylene)oxindole;(3Z)-3-(dimethylaminomethylidene)-1H-indol-2-one;2H-976
• CAS NO: 141210-63-1
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.23
• Mol File: 141210-63-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE(141210-63-1)
• EPA Substance Registry System: 3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE(141210-63-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 141210-63-1(Hazardous Substances Data)

Usage

Description

3-Dimethylaminomethylene-1,3-dihydro-indol-2-one is an organic compound that serves as a crucial intermediate in the synthesis of various complex molecules, particularly those with potential applications in the pharmaceutical and chemical industries. Its unique chemical structure allows it to participate in multiple reactions, making it a versatile building block for the creation of new compounds.

Uses

Used in Pharmaceutical Synthesis:
3-Dimethylaminomethylene-1,3-dihydro-indol-2-one is used as an intermediate in the synthesis of T294270, a derivative of H957770. H957770 is a carcinogen utilized in the study of intestinal bacteria metabolism, which can provide insights into the development of new drugs and therapies targeting cancer and other related diseases.
Used in Chemical Research:
3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE is also used as a research tool in the field of chemical synthesis, particularly for the development of new methodologies and techniques. Its reactivity and structural features make it an attractive candidate for exploring novel synthetic pathways and understanding the underlying chemical reactions.
Used in Food Industry:
3-Dimethylaminomethylene-1,3-dihydro-indol-2-one is created through the heat processing of food, which suggests that it may have potential applications in the food industry. It could be used to study the effects of heat processing on food chemistry and to develop new methods for improving the quality, safety, and nutritional value of processed foods.

Upstream product

• 59-48-3 2-oxoindole 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 57315-91-0 3-Dimethylaminomethylene-2,3-dihydro-1H-indol-2-one 

Downstream Products

• 159212-34-7 3-(phenethylamino-methylene)-indolin-2-one 
• 159212-35-8 3-[1-Phenethylamino-meth-(E)-ylidene]-1,3-dihydro-indol-2-one 
• 947675-24-3 1-benzyl-3-[(dimethylamino)methylidene]-2,3-dihydro-1H-indol-2-one 
• 23872-40-4 (3Z)-3-[(4-methoxyanilino)methylidene]-1,3-dihydro-2H-indol-2-one 
• 159212-39-2 trans-3-oxindole 
• 159212-39-2 cis-3-oxindole 
• 159212-33-6 3-[1-(2-Phenyl-propylamino)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one 

Relevant articles and documents

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A Novel Class of "GABAergic" Agents: 1-Aryl-3-(aminoalkylidene)oxindoles

Antagonism of mercaptopropionic acid (MPA) induced convulsions, reflecting a GABAergic mechanism, was observed in a series of 1-aryl-3-(aminoalkylidene)oxindoles.Optimal MPA antagonism was associated with 3-halo, 3-alkyl, and/or 4-alkoxy substituents in the pendant aryl ring and with (dimethylamino)methylene, 1-(dimethylamino)ethylidene and N-methyl-2-pyrrolidinylidene side chains.The precise mechanism of action of these agents is unclear at this time; however, they are not GABA mimics and they do not affect GABA levels.Like other GABAergic agents, these compounds are potent enhancers of benzodiazepine binding and they antagonize cyclic GMP elevations induced by isoniazid.Compounds from this series may therefore have potential therapeutic utility as anticonvulsants or anxiolytics.