1412807-88-5

Basic information

• Product Name: tert-butyl ((S)-1-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
• Synonyms: tert-butyl ((S)-1-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
• CAS NO: 1412807-88-5
• Molecular Weight: 460.422
• Mol File: 1412807-88-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl ((S)-1-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((S)-1-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate(1412807-88-5)
• EPA Substance Registry System: tert-butyl ((S)-1-((3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate(1412807-88-5)

Safety Data

• Hazardous Substances Data: 1412807-88-5(Hazardous Substances Data)

Downstream Products

• 1132709-16-0 (3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid 

Relevant articles and documents

CU-AND NI-CATALYZED DECARBOXYLATIVE BORYLATION REACTIONS

The invention is directed to methods of converting a carboxylic acid group in a compound, via a redox active ester, to a corresponding boronic ester by treatment with bis(pinacolato)diboron-alkyllithium complex in the presence of a ligand, a Ni(ll) salt or a copper salt, and an Mg(ll) salt, in the presence of an alkyllithium or a lithium hydroxide or alkoxide salt. The product pinacolato boronate ester can be cleaved to provide a boronic acid. The invention is also directed to methods of preparing various compounds of medical value comprising boronic acid groups, and to novel boronic-acid containing compounds of medicinal value, including an atorvastatin boronic acid analog, a vancomycin aglycone boronic acid analog, and boronic acid containing elastase inhibitors mCBK319, mCBK320, mCBK323, and RPX-7009.