141388-76-3

Basic information

• Product Name: (R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• Synonyms: (R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;Besifloxacin;Besivance;3-Quinolinecarboxylicacid,7-[(3R)-3-aMinohexahydro-1H-azepin-1-y;(R)-7-(3-aMinoazepan-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 7-[(3R)-3-aMinohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-;7-[(3R)-3-Amino-1-azepanyl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid;(R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-qu
• CAS NO: 141388-76-3
• Molecular Formula: C19H21ClFN3O3
• Molecular Weight: 393.844
• EINECS: 604-773-0
• Product Categories: APIs
• Mol File: 141388-76-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 606.976 °C at 760 mmHg
• Flash Point: 320.887 °C
• Appearance: /
• Density: 1.469
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.649
• PKA: 6.41±0.50(Predicted)
• CAS DataBase Reference: (R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid(141388-76-3)
• EPA Substance Registry System: (R)-7-(3-Aminohexahydro-1H-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid(141388-76-3)

Safety Data

• Hazardous Substances Data: 141388-76-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow to slightly yellow crystalline powder

Pharmaceutical Applications

An amino-azepinyl quinolone formulated as a suspension for ophthalmic usage. It exhibits good antistaphylococcal activity, as well as activity against Str. pneumoniae, Enterobacteriaceae, H. influenzae and Mor. catarrhalis. It is weakly active against Corynebacterium spp. and has no useful activity against Ps. aeruginosa. After instillation into the eye, less than 0.1% of the drug reaches the plasma. It is used for bacterial conjunctivitis.

InChI:InChI=1/C19H21ClFN3O3/c20-15-16-12(18(25)13(19(26)27)9-24(16)11-4-5-11)7-14(21)17(15)23-6-2-1-3-10(22)8-23/h7,9-11H,1-6,8,22H2,(H,26,27)/t10-/m1/s1

Relevant articles and documents

ACID SALTS OF FLUOROQUINOLONE CARBOXYLIC ACID COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME

The present disclosure is in the field of pharmaceutical and chemical sciences. The present disclosure generally relates to the synthesis of therapeutic agents, processes for preparing said agents, compositions comprising said therapeutic agents and their