141518-55-0

Basic information

• Product Name: (R)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-(4-hydroxyphenyl)acetate
• Synonyms: (R)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-(4-hydroxyphenyl)acetate
• CAS NO: 141518-55-0
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.30436
• Mol File: 141518-55-0.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (R)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-(4-hydroxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-(4-hydroxyphenyl)acetate(141518-55-0)
• EPA Substance Registry System: (R)-Methyl 2-((tert-butoxycarbonyl)aMino)-2-(4-hydroxyphenyl)acetate(141518-55-0)

Safety Data

• Hazardous Substances Data: 141518-55-0(Hazardous Substances Data)

Usage

Description

(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate is a chemical compound that belongs to the group of amino acid derivatives. It is composed of a methyl ester group, a tert-butoxycarbonyl amino group, and a hydroxyphenyl group. (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate is commonly used in organic synthesis and pharmaceutical research as a building block for various bioactive molecules. It has potential applications in drug development and can be used as a precursor for the synthesis of peptide-based drugs and other pharmaceuticals. Additionally, it has been studied for its potential antioxidant and anti-inflammatory properties due to the presence of the 4-hydroxyphenyl group.

Uses

Used in Pharmaceutical Research:
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate is used as a building block in pharmaceutical research for the development of various bioactive molecules. Its unique structure allows for the creation of peptide-based drugs and other pharmaceuticals, making it a valuable compound in the field of drug development.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate is used as a key component in the synthesis of complex organic molecules. Its versatile structure enables the formation of a wide range of compounds, contributing to the advancement of chemical research and innovation.
Used in Antioxidant and Anti-inflammatory Applications:
Due to the presence of the 4-hydroxyphenyl group, (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate has been studied for its potential antioxidant and anti-inflammatory properties. It may be used as a precursor in the development of new treatments for conditions related to oxidative stress and inflammation.
Used in Drug Delivery Systems:
In the development of drug delivery systems, (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate can be utilized as a component in the design of novel carriers for drug molecules. Its unique structure may contribute to improved delivery, bioavailability, and therapeutic outcomes for various pharmaceutical applications.

Upstream product

• 27460-85-1 N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 34619-03-9 tert-butyldicarbonate 
• 57591-61-4 methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride 
• 37763-23-8 D-2-p-hydroxyphenylglycine methyl ester 

Downstream Products

• 761459-43-2 2,5-bis-[4-(tert-butoxycarbonylamino-ethoxycarbonyl-methyl)-phenoxymethyl]-benzoic acid ethyl ester 
• 313490-19-6 methyl N-tert-butoxycarbonyl-4-{[(trifluoromethyl)sulfonyl]oxy}-D-phenylglycinate 
• 1391355-45-5 (R)-4-hydroxyphenylglycinol hydrochloride 

Relevant articles and documents

Preparation method of (-) - Cytoxazone and (+) -4 - epi-Cytoxazone

The preparation method of (-) - Cytoxazone and (+) -4 - epi-Cytoxazone takes D - p-hydroxyphenylglycine as a raw material, the intermediate 2 is obtained through methyl esterification reaction under catalysis of thionyl chloride, and then the amino is protected with Boc anhydride to obtain the intermediate 3. The compound 4 is obtained by using potassium carbonate as a base and reacting with methyl iodide under reflux conditions. The methyl ester was reduced with sodium borohydride/lithium chloride to give the primary alcohol compound 5. An intermediate IBX is then obtained with 6 primary alcohol, then reacted with acetone cyanohydrin SN2 to give intermediate 7, and the intermediate 8 is obtained by reacting with the methanol solution of hydrogen chloride to obtain two five-membered ring compound compounds 9 and 10, respectively, with sodium borohydride to obtain (-) - Cytoxazone and its isomers (+) -4 - epi-Cytoxtoxtoxtoxol, respectively.

Compound, pharmaceutically acceptable salt thereof and medical application thereof

The invention belongs to the field of medicines, and particularly relates to a compound shown as a formula I or medicinal salt thereof. The invention also relates to application of the compound or themedicinal salt thereof in selectively inhibiting LF activity, resisting anthrax toxin toxicity and preventing or treating anthracnose.

APOPTOSIS-INDUCING AGENTS

Provided are certain Bcl-2 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.