1415800-38-2

Basic information

• Product Name: Bromo-PEG5-t-butyl ester
• Synonyms: Br-PEG5-butyl ester;Br-PEG5-t-butyl ester;Br-PEG5-CH2CH2COOtBu
• CAS NO: 1415800-38-2
• Molecular Formula: C17H33BrO7
• Molecular Weight: 429.34372
• Mol File: 1415800-38-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO, DCM,DMF
• CAS DataBase Reference: Bromo-PEG5-t-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Bromo-PEG5-t-butyl ester(1415800-38-2)
• EPA Substance Registry System: Bromo-PEG5-t-butyl ester(1415800-38-2)

Safety Data

• Hazardous Substances Data: 1415800-38-2(Hazardous Substances Data)

Usage

Description

Bromo-PEG5-t-butyl ester is a PEG (polyethylene glycol) linker that features a bromide group and a t-butyl protected carboxyl group. This molecule is designed to enhance solubility in aqueous media due to the hydrophilic PEG spacer. The bromide (Br) acts as an excellent leaving group for nucleophilic substitution reactions, while the t-butyl protected carboxyl group can be deprotected under acidic conditions, making it a versatile compound for various applications.

Uses

Used in Bioconjugation and Drug Synthesis:
Bromo-PEG5-t-butyl ester is used as a bioconjugation agent for the attachment of biomolecules to other molecules or surfaces. The bromide group facilitates nucleophilic substitution reactions, allowing for the efficient coupling of biomolecules such as proteins, peptides, or nucleic acids.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Bromo-PEG5-t-butyl ester is used as a component in drug delivery systems. The hydrophilic PEG spacer improves the solubility and stability of drug molecules, while the t-butyl protected carboxyl group can be deprotected under acidic conditions, enabling controlled release of the drug in specific environments, such as tumor tissues.
Used in Polymer Science:
Bromo-PEG5-t-butyl ester is utilized as a building block in the synthesis of various polymers with specific properties. The bromide group can be used to initiate polymerization reactions, while the PEG spacer and t-butyl protected carboxyl group can be tailored to achieve desired characteristics in the final polymer product.
Used in Surface Modification:
In materials science, Bromo-PEG5-t-butyl ester is used for surface modification of various substrates, such as nanoparticles or solid supports. The hydrophilic PEG spacer can improve the biocompatibility and reduce non-specific interactions, while the bromide group allows for covalent attachment of the molecule to the surface through nucleophilic substitution reactions.
Used in Chemical Synthesis:
Bromo-PEG5-t-butyl ester serves as an intermediate in the synthesis of various complex molecules, such as pharmaceuticals, agrochemicals, and specialty chemicals. The bromide group can be replaced by a wide range of nucleophiles, enabling the introduction of diverse functional groups into the molecule.