1417737-65-5

Basic information

• Product Name: 2-[benzyl[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino]acetonitrile
• Synonyms: 2-[benzyl[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino]acetonitrile
• CAS NO: 1417737-65-5
• Molecular Weight: 348.361
• Mol File: 1417737-65-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[benzyl[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino]acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[benzyl[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino]acetonitrile(1417737-65-5)
• EPA Substance Registry System: 2-[benzyl[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino]acetonitrile(1417737-65-5)

Safety Data

• Hazardous Substances Data: 1417737-65-5(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 4008-48-4 nitroxoline 
• 3010-05-7 benzylaminoacetonitrile 

Relevant articles and documents

Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases

Carbapenemases such as metallo-β-lactamases (MBLs) are spreading among Gram-negative bacterial pathogens. Infections due to these multidrug-resistant bacteria constitute a major global health challenge. Therapeutic strategies against carbapenemase producing bacteria include β-lactamase inhibitor combinations. Nitroxoline is a broad-spectrum antibiotic with restricted indication for urinary tract infections. In this study, we report on nitroxoline as an inhibitor of MBLs. We investigate the structure-activity relationships of nitroxoline derivatives considering in vitro MBL inhibitory potency in a fluorescence based assay using purified recombinant MBLs, NDM-1 and VIM-1. We investigated the most potent nitroxoline derivative in combination with imipenem against clinical isolates as well as transformants producing MBL by broth microdilution and time-kill kinetics. Our findings demonstrate that nitroxoline derivatives are potent MBL inhibitors and in combination with imipenem overcome MBL-mediated carbapenem resistance.