1417802-01-7Relevant articles and documents
Enantioselective and regioselective pyrone Diels-Alder reactions of vinyl sulfones: Total synthesis of (+)-cavicularin
Zhao, Peng,Beaudry, Christopher M.
, p. 10500 - 10503 (2016/02/18)
The total synthesis of (+)-cavicularin is described. The synthesis features an enantio- and regioselective pyrone Diels-Alder reaction of a vinyl sulfone to construct the cyclophane architecture of the natural product. The Diels-Alder substrate was prepared by a regioselective one-pot three-component Suzuki reaction of a non-symmetric dibromoarene. The total synthesis of (+)-cavicularin features an enantio- and regioselective Diels-Alder reaction of a pyrone with a vinyl sulfone. The substrate for this transformation is prepared by a regioselective one-pot three-component Suzuki reaction of a non-symmetric dibromoarene.