1417818-39-3

Basic information

• Product Name: 1-(4-bromo-phenyl)-2-phenyl-ethane-1,2-diol
• Synonyms: 1-(4-bromo-phenyl)-2-phenyl-ethane-1,2-diol
• CAS NO: 1417818-39-3
• Molecular Weight: 293.16
• Mol File: 1417818-39-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-bromo-phenyl)-2-phenyl-ethane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromo-phenyl)-2-phenyl-ethane-1,2-diol(1417818-39-3)
• EPA Substance Registry System: 1-(4-bromo-phenyl)-2-phenyl-ethane-1,2-diol(1417818-39-3)

Safety Data

• Hazardous Substances Data: 1417818-39-3(Hazardous Substances Data)

Upstream product

• 39229-12-4 4-bromobenzil 
• 99-90-1 para-bromoacetophenone 
• 25856-01-3 1-(4-bromophenyl)-3-phenylpropane-1,3-dione 

Relevant articles and documents

Asymmetric transfer hydrogenation of unsymmetrical benzils

In this paper, the asymmetric transfer hydrogenation of unsymmetrical benzils with m, p-substituents was conducted with a substrate/catalyst molar ratio of 100 at 40°C for 24 h to produce (S,S)-hydrobenzoins in good yields (76.2% to 97.1%) with high diastereomeric (syn/anti = 10.8 to 29.7/1) and enantiomeric purities (86.1%ee syn to 98.9%ee syn). Unfortunately, the unsymmetrical benzils with the o-substituents such as electron-donating (R = CH3, OCH3) and electron-withdrawing groups (R = F, Cl, CF3) resulted in poor yields (0% to 31.2%), even at 40°C for 72 h. These products had inefficient diastereoselectivities (syn/anti = 1.5 to 5.0/1) caused by steric effects. Furthermore, the results of a dynamic-kinetic study were used to propose a plausible reaction pathway of unsymmetrical benzil using 3-methoxy-1,2-diphenyl ethanedione as an example.