141859-24-7

Basic information

• Product Name: 4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-1-methyl-5-[(phenylmethylene)amino]-2-thioxo-
• CAS NO: 141859-24-7
• Molecular Formula: C12H12N4OS
• Molecular Weight: 260.319
• Mol File: 141859-24-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-1-methyl-5-[(phenylmethylene)amino]-2-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-1-methyl-5-[(phenylmethylene)amino]-2-thioxo-(141859-24-7)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 6-amino-2,3-dihydro-1-methyl-5-[(phenylmethylene)amino]-2-thioxo-(141859-24-7)

Safety Data

• Hazardous Substances Data: 141859-24-7(Hazardous Substances Data)

Upstream product

• 54030-50-1 6-amino-1-methyl-5-nitroso-2-thiouracil 
• 16837-08-4 6-amino-1-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 
• 875-41-2 5,6-diamino-1,2,3,4-tetrahydro-1-methyl-4-oxo-2-thiopyrimidine 
• 100-52-7 benzaldehyde 

Downstream Products

• 141859-49-6 8-(2-Chloro-phenyl)-3-methyl-2-methylsulfanyl-3,7-dihydro-purin-6-one 
• 141859-48-5 3-Methyl-2-methylsulfanyl-8-phenyl-3,7-dihydro-purin-6-one 
• 141859-60-1 6-Amino-1-methyl-2-methylsulfanyl-5-{[1-phenyl-meth-(E)-ylidene]-amino}-1H-pyrimidin-4-one 
• 103258-00-0 3-methyl-8-phenyl-2-thioxanthine 

Relevant articles and documents

Novel 2-thioxanthine and dipyrimidopyridine derivatives: Synthesis and antimicrobial activity

Several fused imidazolopyrimidines were synthesized starting from 6-amino-1- methyl-2-thiouracil (1) followed by nitrosation, reduction and condensation with different aromatic aldehydes to give Schiff's base. The dehydrocyclization of Schiff's bases using iodine/DMF gave Compounds 5a-g. The methylation of 5a-g using a simple alkylating agent as dimethyl sulfate ((CH3)2SO4) gave either monoalkylated imidazolopyrimidine 6a-g at room temperature or dialkylated derivatives 7a-g on heating 6a-g with ((CH3)2SO4). On the other hand, treatment of 1 with different aromatic aldehydes in absolute ethanol in the presence of conc. hydrochloric acid at room temperature and/or reflux with acetic acid afforded bis-5,5′-diuracylmethylene 8a-e, which cyclized on heating with a mixture of acetic acid/HCl (1:1) to give 9a-e. Compounds 9a-e can be obtained directly by refluxing of Compound 1 with a mixture of acetic acid/HCl. The synthesized new compounds were screened for antimicrobial activity, and the MIC was measured.