14190-09-1Relevant articles and documents
Reaction of Organolead Triacetates with 4-Ethoxycarbonyl-2-methyloxazol-5-one. The Synthesis of α-Aryl and α-Vinyl N-Acetylglycine Ethyl Esters and Their Enzymic Resolution.
Morgan, Jacqueline,Pinhey, John T.
, p. 9625 - 9628 (1994)
An efficient synthesis of the moisture-sensitive compound, 4-ethoxycarbonyl-2-methyloxazol-5-one, has been achieved.This compound undergoes high-yielding arylation and vinylation at the 4-position with organolead triacetates to give compounds which in water are converted to α-aryl and α-vinyl N-acetylglycine ethyl esters.These α-substituted glycine derivatives may be kinetically resolved in very good yield and high enantiomeric excess by enzymic hydrolysis of either the ester group or the amide function of the corresponding carboxylic acids.
Diastereoselective synthesis of arylglycine derivatives by cationic palladium(ll)-catalyzed addition of arylboronic acids to N-tert-butanesulfinyl imino esters
Dai, Huixiong,Lu, Xiyan
, p. 3077 - 3080 (2008/02/11)
A cationic palladium-complex-catalyzed addition of arylboronic acids to N-tert-butanesulfinyl iminoacetates to yield the optically active arylglycine derivatives with moderate to good yield and high diastereoselectivity was developed. This reaction provid
