141917-82-0Relevant articles and documents
Guanine, pyrazolo[3,4-d]pyrimidine, and triazolo[4,5-d]pyrimidine (8-azaguanine) phosphonate acyclic derivatives as inhibitors of purine nucleoside phosphorylase
Beauchamp, Lilia M.,Tuttle, Joel V.,Rodriguez, Martha E.,Sznaidman, Marcos L.
, p. 949 - 956 (2007/10/03)
Phosphonate acyclic derivatives of guanines, pyrazolo[3,4-d]pyrimidines, and triazolo[4,5-d]-pyrimidines (8-azaguanines) are inhibitors of the enzyme purine nucleoside phosphorylase (PNPase) with K′1 values ranging from 0.05 to 1.6 μM. These compounds are enzymatically stable congeners of the potent PNPase inhibitor acyclovir diphosphate (53).
