142273-18-5 Usage
Description
Paullone, a compound with significant biological activities, is known for its potent inhibition of cyclin-dependent kinases (CDKs). These protein kinases play a crucial role in the regulation of the cell cycle, making paullone a promising candidate for various applications in the pharmaceutical and biotechnology industries.
Uses
Used in Pharmaceutical Applications:
Paullone is used as an inhibitor of CDKs for its ability to regulate the cell cycle. This application is particularly relevant in the development of treatments for cancer, as dysregulation of CDKs can lead to uncontrolled cell proliferation and tumor growth.
Used in Biotechnology Applications:
In the biotechnology industry, paullone is utilized as a research tool to study the role of CDKs in cellular processes. By inhibiting these kinases, researchers can gain insights into the mechanisms underlying cell cycle regulation and develop targeted therapies for various diseases.
Used in Drug Development:
Paullone's potent inhibition of CDKs makes it a valuable compound in the development of new drugs. It can be used as a starting point for the design of more selective and effective CDK inhibitors, which could have applications in cancer treatment and other conditions related to cell cycle dysregulation.
Used in Anticancer Applications:
Similar to gallotannin, paullone is employed as an anticancer agent due to its ability to modulate oncological signaling pathways. By targeting CDKs, paullone can inhibit tumor growth and progression, making it a potential therapeutic option for various types of cancer.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of paullone, drug delivery systems can be developed to improve its delivery to target cells. Organic and metallic nanoparticles can be used as carriers for paullone, aiming to increase its therapeutic outcomes and reduce potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 142273-18-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,2,7 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 142273-18:
(8*1)+(7*4)+(6*2)+(5*2)+(4*7)+(3*3)+(2*1)+(1*8)=105
105 % 10 = 5
So 142273-18-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H12N2O/c19-15-9-12-10-5-1-3-7-13(10)18-16(12)11-6-2-4-8-14(11)17-15/h1-8,18H,9H2,(H,17,19)
142273-18-5Relevant articles and documents
Synthesis of 7,12-Dihydro-indolo[3,2-d][1]benzazepin-6-(5H)-ones and 6,11-Dihydro-thieno-[3',2':2,3]azepino[4,5-b]indol-5(4H)-one
Kunick
, p. 297 - 299 (1992)
The title compounds 4 and 6 were prepared by Fischer indole synthesis. 4a is substituted in 10-position by reaction with bromine in glacial acetic acid. A fast ring inversion is observed for the azepine ring in 4 and 6.
A Synthesis of Multifunctionalized Indoles from [3 + 2] Annulation of 2-Bromocyclopropenes with Anilines
Cao, Zhu,Zhu, Jian-Bo,Wang, Lijia,Liao, Saihu,Tang, Yong
, (2019)
A new regioselective method for the synthesis of multifunctionalized indoles from [3 + 2] annulation of 2-bromocyclopropenes with anilines has been developed. By employing a nickel complex as a catalyst, 27 examples of indole products were obtained in goo
N-Heterocyclic carbene (NHC)-catalysed atom economical construction of 2,3-disubstituted indoles
Harish, Battu,Subbireddy, Manyam,Suresh, Surisetti
, p. 3338 - 3341 (2017/03/22)
A novel organocatalytic approach, harnessing the unique reactivities of N-heterocyclic carbenes (NHCs), has been revealed for the construction of indoles. The NHC-catalysed atom economical synthesis of a wide range of 2-substituted indole-3-acetic acid derivatives is displayed. Strategic application of the developed method was demonstrated for a short synthesis of a cyclin-dependent kinase (CDK) inhibitor: paullone.
