1422955-31-4

Basic information

• Product Name: 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
• Synonyms: 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-;HIF-C2;HIF-2 Antagonist 2;N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine;HIF-2 inhibitor 2;HIF Inhibitor VII - Calbiochem;N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
• CAS NO: 1422955-31-4
• Molecular Formula: C₁₂H₆ClFN₄O₃
• Molecular Weight: 308.6524432
• Mol File: 1422955-31-4.mol
• Article Data: 2

Chemical Properties

• Appearance: white to beige/
• Storage Temp.: room temp
• Solubility: DMSO: soluble15mg/mL, clear
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
• CAS DataBase Reference: 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-(1422955-31-4)
• EPA Substance Registry System: 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-(1422955-31-4)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 1422955-31-4(Hazardous Substances Data)

Usage

Description

2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitrois a chemical compound characterized by its unique molecular structure, which consists of a benzoxadiazole core with amine, chloro, and fluoro substituents, as well as a nitro group. 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitrois known for its potential applications in various fields due to its distinct chemical properties.

Uses

Used in Pharmaceutical Industry:
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitrois used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs with specific therapeutic properties.
Used in Chemical Research:
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitrois also utilized in chemical research as a model system to study the reactivity and properties of benzoxadiazole derivatives. Researchers can use this compound to gain insights into the behavior of similar molecules and develop new synthetic strategies or applications.
Used in Material Science:
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitromay also find applications in the field of material science, particularly in the development of new materials with specific properties. Its unique structure and functional groups could contribute to the creation of materials with enhanced performance characteristics, such as improved stability, reactivity, or selectivity.

References

1) Scheuermann?et al.?(2013),?Allosteric inhibition of hypoxia inducible factor-2 with small molecules; Nat. Chem. Biol.,?9?271 2) Masetti?et al.?(2014),?Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding; PLoS One,?9(4)?e94986 3) Rodgers?et al.?(2013),?Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor; J. Med. Chem.,?56 1739

Upstream product

• 4863-91-6 3-chloro-5-fluoroaniline 
• 5714-17-0 5-chloro-4-nitrobenzo[c]-[1,2,5]oxadiazole 

Downstream Products

• 1422955-40-5 C₁₂H₈ClFN₄O 
• 1422955-41-6 C₁₄H₁₀ClFN₄O₂ 
• 1422955-42-7 C₁₄H₉Cl₂FN₄O₂ 
• 1422955-43-8 C₁₆H₈ClFN₄O₃ 

Relevant articles and documents

INHIBITION OF HIF-2α HETERODIMERIZATION WITH HIF1β (ARNT)

Provided is a method of inhibiting heterodimerization of HIF-2α to HIF1β (ARNT) comprising binding certain small molecules to the HIF-2α PAS-B domain cavity but not to HIF1α and inhibiting HIF-2α heterodimerization to HIF1β (ARNT) but not inhibiting HIF1α