142326-59-8

Basic information

• Product Name: L-701,324
• Synonyms: 7-CHLORO-4-HYDROXY-3-(3-PHENOXY)PHENYL-2(1H)-QUINOLINONE;7-CHLORO-4-HYDROXY-3-(3-PHENOXY )PHENYLQUINOLIN-2[1H]-ONE;7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(H)-quinolinone;L-701,304;7-chloro-1-(4-hydroxy-3-phenoxyphenyl)quinolin-2(1H)-one;L-701;L-701,324
• CAS NO: 142326-59-8
• Molecular Formula: C₂₁H₁₄ClNO₃
• Molecular Weight: 363.79
• Product Categories: Inhibitors
• Mol File: 142326-59-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 308 °C
• Boiling Point: 540.9°Cat760mmHg
• Flash Point: 280.9°C
• Appearance: /
• Density: 1.389g/cm³
• Vapor Pressure: 1.57E-12mmHg at 25°C
• Refractive Index: 1.679
• Storage Temp.: Store at RT
• Solubility: DMSO: soluble36.4mg/mL
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: L-701,324(CAS DataBase Reference)
• NIST Chemistry Reference: L-701,324(142326-59-8)
• EPA Substance Registry System: L-701,324(142326-59-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 142326-59-8(Hazardous Substances Data)

Usage

Description

L-701,324 is a compound that acts as a potential anticonvulsant with high selectivity and affinity for the N-methyl-D-aspartate (NMDA) receptor glycine site. It has been identified for its potential therapeutic applications, particularly in the treatment of neurological disorders and cancer.

Uses

Used in Pharmaceutical Industry:
L-701,324 is used as an anticonvulsant for its ability to selectively target the NMDA receptor glycine site, which may help in the treatment of various neurological disorders, such as epilepsy and other seizure-related conditions.
Used in Oncology:
L-701,324 is used as a potential therapeutic agent for small-cell lung cancer (SCLC) due to the expression of NMDA receptors in these cancer cells. Targeting these receptors may lead to effective treatment strategies for SCLC patients.

Biological Activity

An orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.

InChI:InChI=1/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)

Upstream product

• 250339-84-5 methyl 4-chloro-2-[[2-(3-phenoxyphenyl)acetyl]amino]benzoate 
• 108-42-9 3-chloro-aniline 
• 86750-63-2 m-phenoxyphenylacetic acid chloride 
• 32852-81-6 (3-phenoxyphenyl)acetic acid 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 

Relevant articles and documents

Rapid microwave-enhanced synthesis of 4-hydroxyquinolinones under solvent-free conditions

3-Aryl-4-hydroxyquinolin-2(1H)-ones are potent and selective glycine-site NMDA receptor antagonists of pharmaceutical interest. A novel microwave-enhanced synthesis of such quinolinones under solvent-free conditions has been developed. The quinolinones ar

3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: Orally active antagonists of the glycine site on the NMDA receptor [1]

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