1423803-24-0

Basic information

• Product Name: Apixaban Impurity 12
• Synonyms: Apixaban Impurity 12
• CAS NO: 1423803-24-0
• Molecular Formula: C₂₀H₁₉N₅O₃
• Molecular Weight: 377.4
• Mol File: 1423803-24-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 656.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• PKA: 15.03±0.20(Predicted)
• CAS DataBase Reference: Apixaban Impurity 12(CAS DataBase Reference)
• NIST Chemistry Reference: Apixaban Impurity 12(1423803-24-0)
• EPA Substance Registry System: Apixaban Impurity 12(1423803-24-0)

Safety Data

• Hazardous Substances Data: 1423803-24-0(Hazardous Substances Data)

Usage

General Description

Apixaban Impurity 12 is a chemical impurity that is associated with the anticoagulant apixaban. It is characterized by its molecular formula, C21H19N5O4, and has a molecular weight of 397.41 g/mol. This impurity can have potential effects on the efficacy and safety of the drug, and as such, it is important to monitor and control its presence in pharmaceutical formulations of apixaban. Analytical methods such as high-performance liquid chromatography (HPLC) and mass spectrometry are commonly used to detect and quantify Apixaban Impurity 12 in drug samples. Efforts are typically made to minimize the presence of this impurity in the final drug product to ensure its quality and effectiveness for medical use.

Upstream product

• 159217-89-7 N-Boc-4-iodoaniline 
• 93298-14-7 (4-iodophenyl)carbamic acid phenylmethyl ester 
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• 4509-90-4 5-bromovaleroyl chloride 
• 100-01-6 4-nitro-aniline 
• 473927-63-8 ethyl (2Z)-chloro[2-(4-methoxyphenyl)hydrazinylidene]ethanoate 
• 104-94-9 4-methoxy-aniline 
• 38560-30-4 1-(4-nitrophenyl)piperidine-2-one 

Downstream Products

• 1437577-94-0 6-(4-(5-bromopentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 
• 1449510-64-8 6-(4-(5-chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 

Relevant articles and documents

Preparation method of apixaban (by machine translation)

L - (3 - methoxyphenyl) 4 - oxo 1 - (4 - nitrophenyl) piperidine -2 - ketone -4 - (V), 1 - 4 -2 - tetrahydro - 111H-pyrazolo [4 - c -3, 3 -] pyridine -4 - formamide (V) are obtained by reductive amination, and 4 -oxo -6 -n-pentanoic acid ester is subjected to reductive amination, and the molecule is subjected to 5 - amidation reaction to form the apixaban 4 - (-4 I). the method comprises the following steps of reductive amination -7 - and acid salt condensation 4 5 - 6-7 - methoxyphenyl) reaction, 3 and carrying out -3 - hydrogenation reduction reaction. The method is simple to operate, safe, green, low in cost, high in selectivity, and high yield and purity of products. (by machine translation)

PROCESS FOR THE PREPARATION OF APIXABAN

A crystalline Form N-1 of apixaban substantially free from one or more of: 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid; 7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-1-phenyl-4,5,6,

AN IMPROVED PROCESS FOR THE PREPARATION OF APIXABAN AND INTERMEDIATES THEREOF

The present invention relates to an improved process for the preparation of apixaban and intermediates thereof. In particular, the invention relates to an improved process for the preparation of an amorphous form of apixaban. The invention also relates to a pharmaceutical composition comprising an amorphous form of apixaban for oral administration as an antithrombotic agent.