1424-00-6 Usage
Description
Mesterolone, also known as a synthetic anabolic-androgenic steroid (AAS) and a derivative of dihydrotestosterone (DHT), is a 3-oxo-5alpha-steroid. It is characterized by the addition of a methyl group at the carbon one position, which allows it to survive oral ingestion by protecting it from hepatic breakdown. Mesterolone is considered a weak androgen due to its inactivation by 3α-hydroxysteroid dehydrogenase in skeletal muscles and is not a substrate for aromatase, meaning it is not converted into estrogen. It is available as an analytical reference standard and is regulated as a Schedule III drug in the United States.
Uses
Used in Medical Applications:
Mesterolone is used as a replacement therapy for patients with low testosterone or symptoms of aging male syndrome. Its weak androgenic activity and inability to be aromatized to estrogens make it a suitable choice for such treatments.
Used in Sports Performance Enhancement:
Mesterolone is used as a performance-enhancing drug in sports, aiming to improve athlete performance. Its anabolic and androgenic properties contribute to increased muscle mass and strength, making it a popular choice among athletes.
Used in Research and Forensic Applications:
Mesterolone is used as an active ingredient in various pharmaceutical preparations for research purposes. Its structural properties and effects on the body make it a valuable compound for studying the mechanisms of anabolic and androgenic steroids.
Used in Treatment of Depression:
Experiments are still ongoing to explore the potential use of Mesterolone as a treatment for depression. Its effects on mood and mental health are being investigated, and it may offer a new avenue for therapeutic intervention in the future.
Chemical Properties:
Mesterolone is a white or yellowish crystalline powder, which is an important characteristic for its identification and application in various fields.
Originator
Proviron,Schering,W. Germany,1967
Manufacturing Process
500 mg of 1α-methyl-androstan-17β-ol-3-one-17-acetate are heated under reflux for 90 minutes in a nitrogen atmosphere in 5 ml of 4% methanolic sodium hydroxide solution. The reaction mixture is then stirred into ice water,the precipitated product filtered with suction and recrystallized from isopropyl
ether. 1α-Methyl-androstan-17β-ol-3-one melts at 203.5° to 205°C.
Therapeutic Function
Androgen
Check Digit Verification of cas no
The CAS Registry Mumber 1424-00-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,2 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1424-00:
(6*1)+(5*4)+(4*2)+(3*4)+(2*0)+(1*0)=46
46 % 10 = 6
So 1424-00-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h12-13,15-18,22H,4-11H2,1-3H3/t12-,13-,15-,16-,17-,18-,19-,20-/m0/s1
1424-00-6Relevant articles and documents
USE OF alpha,beta -UNSATURATED CARBONYL COMPOUNDS AS QUENCH REAGENTS FOR THE BIRCH REDUCTION
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Page/Page column 1, (2009/01/20)
Use of α,β-unsaturated carbonyl compounds as quench reagents for the Birch reduction.
Process for the preparation of androstane-3,17-dione derivatives
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, (2008/06/13)
A process for the preparation of androstane-3,17-dione compounds of the formula STR1 wherein X is 1,2-methylene or 1- or 2-methyl, comprises fermenting a sterol of the formula STR2 wherein X is as above and R1 is the hydrocarbon residue of 8-10 carbon atoms, of a sterol, with a microorganism culture capable of effecting the side chain degradation of sterols.