1424351-63-2

Basic information

• Product Name: 1-[2-hydroxy-4,6-dimethoxy-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]ethanone
• Synonyms: 1-[2-hydroxy-4,6-dimethoxy-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]ethanone
• CAS NO: 1424351-63-2
• Molecular Weight: 276.292
• Mol File: 1424351-63-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-[2-hydroxy-4,6-dimethoxy-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-hydroxy-4,6-dimethoxy-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]ethanone(1424351-63-2)
• EPA Substance Registry System: 1-[2-hydroxy-4,6-dimethoxy-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]ethanone(1424351-63-2)

Safety Data

• Hazardous Substances Data: 1424351-63-2(Hazardous Substances Data)

Upstream product

• 1424351-62-1 5-(2,4,6-trimethoxy-phenyl)-1H-pyrazole 
• 1421615-10-2 1-methyl-5-(2,4,6-trimethoxy-phenyl)-1H-pyrazole 
• 108-24-7 acetic anhydride 
• 832-58-6 1-(2,4,6-trimethoxyphenyl)ethanone 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 621-23-8 1,2,3-trimethoxybenzene 

Downstream Products

• 1424351-78-9 C₂₁H₁₈N₂O₄ 
• 1424351-64-3 (E)-1-(2-hydroxy-4,6-dimethoxy-3-(1-methyl-1H-pyrazol-5-yl)phenyl)-3-phenylprop-2-en-1-one 
• 1424351-65-4 (E)-3-(4-fluorophenyl)-1-(2-hydroxy-4,6-dimethoxy-3-(1-methyl-1H-pyrazol-5-yl)phenyl)prop-2-en-1-one 
• 1424351-79-0 C₂₁H₁₇FN₂O₄ 
• 1424351-66-5 (E)-3-(2,4-difluorophenyl)-1-(2-hydroxy-4,6-dimethoxy-3-(1-methyl-1H-pyrazol-5-yl)phenyl)prop-2-en-1-one 
• 1424351-80-3 C₂₁H₁₆F₂N₂O₄ 
• 1424351-67-6 (E)-3-(2,4-dichlorophenyl)-1-(2-hydroxy-4,6-dimethoxy-3-(1-methyl-1H-pyrazol-5-yl)phenyl)prop-2-en-1-one 
• 1424351-81-4 C₂₁H₁₆Cl₂N₂O₄ 
• 1424351-68-7 (E)-3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxy-3-(1-methyl-1H-pyrazol-5-yl)phenyl)prop-2-en-1-one 
• 1424351-69-8 (E)-3-(3,4-difluorophenyl)-1-(2-hydroxy-4,6-dimethoxy-3-(1-methyl-1H-pyrazol-5-yl)phenyl)prop-2-en-1-one 
• 1424351-83-6 C₂₁H₁₆F₂N₂O₄ 
• 1424351-70-1 (E)-3-(benzo[d][1,3]dioxol-5-yl)-1-(2-hydroxy-4,6-dimethoxy-3-(1-methyl-1H-pyrazol-5-yl)phenyl)prop-2-en-1-one 
• 1424351-71-2 (E)-1-(2-hydroxy-4,6-dimethoxy-3-(1-methyl-1H-pyrazol-5-yl)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one 
• 1424351-85-8 C₂₄H₂₄N₂O₇ 

Relevant articles and documents

Design, synthesis, characterization and in vitro and in vivo anti-inflammatory evaluation of novel pyrazole-based chalcones

A series of novel pyrazole-based chalcones have been designed, synthesized from 1-methyl-5-(2,4,6-trimethoxyphenyl)-1H-pyrazole (6). The structures of regioisomers 6 and 7 were determined by 2D 1H-1H COSY, 1H-13C HSQC and 1H-13C HMBC experiments. The newly synthesized compounds were tested for their inhibitory activity against COX-1 and COX-2 using an in vitro cyclooxygenase (COX) inhibition assay. Moreover, they were investigated in vivo for their anti-inflammatory activities using carrageenan-induced rat paw edema model for acute inflammation and cotton pellet-induced granuloma model for chronic inflammation. All the synthesized compounds showed potential to demonstrate anti-inflammatory activities, of particular interest compounds 10i, 10e , 10f, and 10h were found to be potent anti-inflammatory agents.