142606-21-1

Basic information

• Product Name: Urea, N-[(1R)-1-benzo[b]thien-2-ylethyl]-N-hydroxy-
• CAS NO: 142606-21-1
• Molecular Formula: C11H12N2O2S
• Molecular Weight: 236.294
• Mol File: 142606-21-1.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Urea, N-[(1R)-1-benzo[b]thien-2-ylethyl]-N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-[(1R)-1-benzo[b]thien-2-ylethyl]-N-hydroxy-(142606-21-1)
• EPA Substance Registry System: Urea, N-[(1R)-1-benzo[b]thien-2-ylethyl]-N-hydroxy-(142606-21-1)

Safety Data

• Hazardous Substances Data: 142606-21-1(Hazardous Substances Data)

Upstream product

• 1118-02-1 trimethylsilyl isocyanate 
• 118564-89-9 1-(N-hydroxyamino)-1-(benzothien-2-yl)ethane 
• 51868-95-2 1-(benzo[b]thiophen-2-yl)ethanol 
• 127-07-1 N-hydroxyurea 
• 3541-37-5 benzothiophene-2-carboxaldehyde 
• 590-28-3 potassium cyanate 
• 26929-23-7 acetic acid 1-benzo[b]thiophen-2-ylethyl ester 
• 1026256-93-8 phenyl 1-(benzo[b]thiophen-2-yl)ethyl(hydroxyl)carbamate 
• 57-13-6 urea 
• 22720-75-8 2-acetyl benzo[b]thiophene 
• 7803-49-8 hydroxylamine 
• 598-55-0 methyl carbamate 
• 158530-81-5 N-(2-Benzenesulfonyl-1-benzo[b]thiophen-2-yl-ethyl)-hydroxylamine 
• 158530-79-1 2-((E)-2-Benzenesulfonyl-vinyl)-benzo[b]thiophene 

Downstream Products

• 118569-21-4 N-hydroxy-N-(1-benzo[b]thien-2-ylethyl) urea sodium salt 

Relevant articles and documents

Process for the Preparation of Zileuton

The invention discloses a process for the preparation of Zileuton of formula I by employing acetic acid-1-benzo[b]thiophen-2-yl-ethyl-ester of formula-III as an intermediate.

IMPROVED PROCESS FOR THE PREPARATION OF (±)-1-(1-BENZO[B]THIEN-2-YLETHYL)-1-HYDROXYUREA

The present invention relates to an improved process for the preparation of (±)-1-(I -Benzo[b]thien-2-ylethyl)-1-hydroxyurea compound of formula 1.

PROCESS FOR THE PREPARATION OF ZILEUTON

Process for preparing a compound of formula (I), or a salt thereof, comprising reacting of a compound of formula (II) wherein X and R are as herein defined; with a compound of formula (III) [in-line-formulae]NH2OZ??(III)[/in-line-formulae] wherein Z is a hydroxy protecting group, in presence of a catalyst, to obtain a compound of formula (IV), or a salt thereof, removing the hydroxyl protecting group to obtain a compound of formula (V), or a salt thereof; converting a compound of formula (V), or a salt thereof, into a compound of formula (I), or a salt thereof; and, if desired, converting a compound of formula (I) into a salt thereof, or vice versa.