1426425-82-2

Basic information

• Product Name: N-tert-butyl-2-(1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-6-fluoro-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide
• CAS NO: 1426425-82-2
• Molecular Weight: 722.862
• Mol File: 1426425-82-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-tert-butyl-2-(1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-6-fluoro-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butyl-2-(1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-6-fluoro-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide(1426425-82-2)
• EPA Substance Registry System: N-tert-butyl-2-(1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-6-fluoro-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide(1426425-82-2)

Safety Data

• Hazardous Substances Data: 1426425-82-2(Hazardous Substances Data)

Upstream product

• 875781-43-4 2-bromo-5H-pyrrolo[2,3-b]pyrazine 
• 1422773-02-1 6-fluoro-3-tributylstannanyl-1H-indazole 
• 1422773-04-3 N-tert-butyl-2-(6-fluoro-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide 
• 76099-47-3 rac-O-isopropylidene-3,4-dihydroxybutyl methanesulfonate 
• 5754-34-7 4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane 
• 1422773-00-9 2-bromo-N-tert-butyl-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide 
• 1422772-99-3 2-bromo-N-tert-butyl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide 
• 1422772-78-8 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid 
• 885522-07-6 6-fluoro-3-iodo-1H-indazole 

Relevant articles and documents

Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors

We describe the discovery of several pyrrolopyrazines as potent and selective Syk inhibitors and the efforts that eventually led to the desired improvements in physicochemical properties and human whole blood potencies. Ultimately, our mouse model revealed unexpected toxicity that precluded us from further advancing this series.