1427789-19-2

Basic information

• Product Name: C₁₃H₁₀N₂O₂
• CAS NO: 1427789-19-2
• Molecular Weight: 226.235
• Mol File: 1427789-19-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₀N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₀N₂O₂(1427789-19-2)
• EPA Substance Registry System: C₁₃H₁₀N₂O₂(1427789-19-2)

Safety Data

• Hazardous Substances Data: 1427789-19-2(Hazardous Substances Data)

Upstream product

• 42816-53-5 5-Aminoisatin 
• 98-01-1 furfural 
• 20876-36-2 5-amino-1,3-dihydro-2H-indol-2-one 

Relevant articles and documents

Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis

A series of novel indolin-2-ones inhibitors against p90 ribosomal S6 protein kinase 2 (RSK2) were designed and synthesized and their structure-activity relationship (SAR) was studied. The most potent inhibitor, compound 3s, exhibited potent inhibition against RSK2 with an IC50 value of 0.5 μM and presented a satisfactory selectivity against 23 kinases. The interactions of these inhibitors with RSK2 were investigated based on the proposed binding poses with molecular docking simulation. Four compounds and six compounds exhibited moderate anti-proliferation activities against PC 3 cells and MCF-7 cells, respectively.