1428147-73-2

Basic information

• Product Name: C₁₄H₉BrF₂N₂O₃
• CAS NO: 1428147-73-2
• Molecular Weight: 371.138
• Mol File: 1428147-73-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₉BrF₂N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₉BrF₂N₂O₃(1428147-73-2)
• EPA Substance Registry System: C₁₄H₉BrF₂N₂O₃(1428147-73-2)

Safety Data

• Hazardous Substances Data: 1428147-73-2(Hazardous Substances Data)

Upstream product

• 533-75-5 2-hydroxy-2,4,6-cycloheptatrien-1-one 
• 2297-94-1 5-nitrosotropolone 
• 190774-48-2 2-bromo-4,6-difluorophenyl isocyanate 
• 7021-46-7 5-aminotropolone 

Relevant articles and documents

Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: Tropolones as inhibitors of P. aeruginosa elastase

Tropolone emerged from the screening of a chelator fragment library (CFL) as an inhibitor of the Zn2+-dependent virulence factor, Pseudomonas aeruginosa elastase (LasB). Based on this initial hit, a series of substituted tropolone-based LasB inhibitors was prepared, and a compound displaying potent activity in vitro and in a bacterial swarming assay was identified. Importantly, this inhibitor was found to be specific for LasB over other metalloenzymes, validating the usage of tropolone as a viable scaffold for identifying first-in-class LasB inhibitors.