1428346-04-6

Basic information

• Product Name: (Z)-(tetrahydrofuran-2-yl)methyl 2-bromo-3-(phenylamino)acrylate
• Synonyms: (Z)-(tetrahydrofuran-2-yl)methyl 2-bromo-3-(phenylamino)acrylate
• CAS NO: 1428346-04-6
• Molecular Weight: 326.19
• Mol File: 1428346-04-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (Z)-(tetrahydrofuran-2-yl)methyl 2-bromo-3-(phenylamino)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-(tetrahydrofuran-2-yl)methyl 2-bromo-3-(phenylamino)acrylate(1428346-04-6)
• EPA Substance Registry System: (Z)-(tetrahydrofuran-2-yl)methyl 2-bromo-3-(phenylamino)acrylate(1428346-04-6)

Safety Data

• Hazardous Substances Data: 1428346-04-6(Hazardous Substances Data)

Upstream product

• 2399-48-6 tetrahydrofurfuryl acrylate 
• 62-53-3 aniline 

Relevant articles and documents

Palladium-catalyzed oxidative C-N bond coupling involving a solvent-controlled regioselective bromination process

Stereoselective palladium-catalyzed oxidative C-N bond coupling reactions between aromatic amines and alkenes involving a solvent-controlled regioselective bromination process under 1 atm of oxygen atmosphere are disclosed, providing easy access to two different brominated enamines. The addition of hydrogen peroxide (30% aq) as a co-oxidant in the system is crucial for the dehydrogenative aminohalogenation under molecular oxygen (1 atm), and in such a case, the C-N bond coupling/electrophilic bromination reaction cascade is proposed. Furthermore, the different reaction media leads to a switched regioselectivity of the process.