142843-10-5

Basic information

• Product Name: 4-[2-[[(2R,3S)-3-(t-Butoxycarbonylamino)-4-cyclohexyl-2-hydroxy-1-butyl]thio]acetyl]-1-methylpiperazine
• Synonyms: 4-[2-[[(2R,3S)-3-(t-Butoxycarbonylamino)-4-cyclohexyl-2-hydroxy-1-butyl]thio]acetyl]-1-methylpiperazine
• CAS NO: 142843-10-5
• Molecular Weight: 443.651
• Mol File: 142843-10-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[2-[[(2R,3S)-3-(t-Butoxycarbonylamino)-4-cyclohexyl-2-hydroxy-1-butyl]thio]acetyl]-1-methylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-[[(2R,3S)-3-(t-Butoxycarbonylamino)-4-cyclohexyl-2-hydroxy-1-butyl]thio]acetyl]-1-methylpiperazine(142843-10-5)
• EPA Substance Registry System: 4-[2-[[(2R,3S)-3-(t-Butoxycarbonylamino)-4-cyclohexyl-2-hydroxy-1-butyl]thio]acetyl]-1-methylpiperazine(142843-10-5)

Safety Data

• Hazardous Substances Data: 142843-10-5(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 142843-07-0 ethyl 2-<<(2R,3S)-3-<(tert-butoxycarbonyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetate 
• 107202-61-9 (2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane 

Downstream Products

• 142843-31-0 1-<2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetyl>-4-methylpiperazine 
• 142866-95-3 4-((S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-2-{(1S,2R)-1-cyclohexylmethyl-2-hydroxy-3-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethylsulfanyl]-propylcarbamoyl}-ethyl)-imidazole-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

RENIN INHIBITORS CONTAINING THE 2-[[(2R,3S)-3-AMINO-4-CYCLOHEXYL-2-HYDROXY-1-BUTYL]THIO]ALKANOYL MOIETY AND THE CORRESPONDING SULFOXIDE AND SULFONE DERIVATIVES

Compounds of the formula: STR1 which are potent inhibitors of human renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory compounds