142847-17-4

Basic information

• Product Name: 4-AMINO-2-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOBUTANOIC ACID
• Synonyms: 4-AMINO-2-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOBUTANOIC ACID;TERT-BUTOXYCARBONYL ASPARAGINE;Boc-DL-asparagine;2-[(tert-butoxycarbonyl)amino]-3-carbamoylpropanoic acid;N2-(tert-Butoxycarbonyl)asparagine
• CAS NO: 142847-17-4
• Molecular Formula: C₉H₁₆N₂O₅
• Molecular Weight: 232.23
• EINECS: 231-405-2
• Mol File: 142847-17-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 179℃
• Boiling Point: 481.7°Cat760mmHg
• Flash Point: 245.1°C
• Appearance: /
• Density: 1.253g/cm³
• Vapor Pressure: 1.33E-10mmHg at 25°C
• Refractive Index: 1.496
• CAS DataBase Reference: 4-AMINO-2-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOBUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOBUTANOIC ACID(142847-17-4)
• EPA Substance Registry System: 4-AMINO-2-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOBUTANOIC ACID(142847-17-4)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 142847-17-4(Hazardous Substances Data)

Usage

General Description

4-AMINO-2-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOBUTANOIC ACID is a chemical compound with the molecular formula C10H18N2O5. It is a derivative of the amino acid proline and is commonly used in the synthesis of peptides and other organic compounds. 4-AMINO-2-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOBUTANOIC ACID is also known as Boc-L-Proline, and it is frequently used as a protective group for amino acids during peptide synthesis. It is a white to off-white powder that is soluble in organic solvents and has a melting point of around 70-75°C. Boc-L-Proline is widely utilized in the pharmaceutical and biotechnology industries for the production of various peptide-based drugs and as a building block for synthesizing complex organic molecules.

InChI:InChI=1/C9H16N2O5/c1-9(2,3)16-8(15)11-5(7(13)14)4-6(10)12/h5H,4H2,1-3H3,(H2,10,12)(H,11,15)(H,13,14)

Upstream product

• 4530-20-5 BOC-glycine 
• 144-48-9 iodacetamide 
• 104199-82-8 N-butyloxycarbonyl-D-asparagine p-nitrophenyl ester 
• 2058-58-4 (R)-Asparagine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3130-87-8 DL-asparagine monohydrate 
• 3130-87-8 ASPARAGINE 

Downstream Products

• 124842-29-1 (S)-2-(tert-butoxycarbonylamino)pyrrolidine-2,5-dione 
• 61040-22-0 N^β-benzyloxycarbonyl-N^α-Boc-(R)-β-aminoalanine methyl ester 
• 81306-93-6 N²-tert-butoxycarbonyl-N³-benzyloxycarbonyl-D-2,3-diaminopropanoic acid 
• 335280-58-5 tert-butyl N-[1-(cyanomethyl)-2-hydroxyethyl]carbamate 
• 88147-56-2 N-t-butyloxycarbonyl-D-asparagine, benzhydrylester 
• 163929-77-9 tert-butyl (2,5-dioxopyrrolidin-3-yl)carbamate 
• 159002-17-2 N^α-Boc-α,β-diaminopropionic acid 
• 163929-77-9 3-(N-tBoc-D-amino)succinimide 
• 1428095-72-0 O-benzyl N-(tert-butoxycarbonyl)-D-asparaginate 
• 159652-30-9 (R)-2,3-bis-tert-butoxycarbonylaminopropionic acid 
• 1429555-43-0 C₂₃H₃₆N₄O₅ 
• 1429555-68-9 C₂₃H₄₂N₄O₅ 
• 130539-04-7 N-t-butyloxycarbonyl-3-cyano-D-alanine, benzhydrylester 
• 73888-92-3 diphenylmethyl D-4-(p-acetylphenoxy)-2-(1-t-butoxyformamido)butyrate 

Relevant articles and documents

SUBSTITUTED PYRIMIDINIUM COMPOUNDS AND DERIVATIVES FOR COMBATING ANIMAL PESTS

The present invention relates to substituted pyrimidinium compounds of formula (I), to the stereoisomers, salts, tautomers and N-oxides thereof and to compositions comprising such compounds. The invention also relates to methods and uses of these substitu

Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules

The gene cluster responsible for synthesis of the unknown molecule colibactin has been identified in mutualistic and pathogenic Escherichia coli. The pathway endows its producer with a long-term persistence phenotype in the human bowel, a probiotic activity used in the treatment of ulcerative colitis, and a carcinogenic activity under host inflammatory conditions. To date, functional small molecules from this pathway have not been reported. Here we implemented a comparative metabolomics and targeted structural network analyses approach to identify a catalog of small molecules dependent on the colibactin pathway from the meningitis isolate E. coli IHE3034 and the probiotic E. coli Nissle 1917. The structures of 10 pathway-dependent small molecules are proposed based on structural characterizations and network relationships. The network will provide a roadmap for the structural and functional elucidation of a variety of other small molecules encoded by the pathway. From the characterized small molecule set, in vitro bacterial growth inhibitory and mammalian CNS receptor antagonist activities are presented.

Kinase inhibitor compounds

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.