1429-24-9

Basic information

• Product Name: ethyl 4-({[4-(ethoxycarbonyl)phenyl]carbamothioyl}amino)benzoate
• Synonyms: benzoic acid, 4,4'-(carbonothioyldiimino)bis-, diethyl ester; Ethyl 4-({[4-(ethoxycarbonyl)phenyl]carbamothioyl}amino)benzoate
• CAS NO: 1429-24-9
• Molecular Formula: C₁₉H₂₀N₂O₄S
• Molecular Weight: 372.4381
• Mol File: 1429-24-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 504.1°C at 760 mmHg
• Flash Point: 258.7°C
• Density: 1.299g/cm³
• Vapor Pressure: 2.73E-10mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: ethyl 4-({[4-(ethoxycarbonyl)phenyl]carbamothioyl}amino)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-({[4-(ethoxycarbonyl)phenyl]carbamothioyl}amino)benzoate(1429-24-9)
• EPA Substance Registry System: ethyl 4-({[4-(ethoxycarbonyl)phenyl]carbamothioyl}amino)benzoate(1429-24-9)

Safety Data

• Hazardous Substances Data: 1429-24-9(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 94-09-7 p-aminoethylbenzoate 
• 463-71-8 thiophosgene 
• 1205-06-7 4-ethoxycarbonylphenyl isothiocyanate 
• 64-17-5 ethanol 
• 7722-84-1 dihydrogen peroxide 

Downstream Products

• 745-92-6 bis-(4-ethoxycarbonyl-phenyl)-carbodiimide 

Relevant articles and documents

Synthesis, characterization, and pharmacological evaluation of thiourea derivatives

Thioureas and their derivatives are organosulfur compounds having applications in numerous fields such as organic synthesis and pharmaceutical industries. Symmetric thiourea derivatives were synthesized by the reaction of various anilines with CS2. The synthesized compounds were characterized using the UV-visible and nuclear magnetic resonance (NMR) spectroscopic techniques. The compounds were screened for in vitro inhibition of α-amylase, α-glucosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) enzymes and for their antibacterial and antioxidant potentials. These compounds were fed to Swiss male albino mice to evaluate their toxicological effects and potential to inhibit glucose-6-phosphatase (G6Pase) inhibition. The antibacterial studies revealed that compound 4 was more active against the selected bacterial strains. Compound 1 was more active against 2,2-diphenyl-1-picrylhydrazyl and 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radicals, AChE, BuChE, and α-glucosidase. Compound 2 was more potent against α-amylase and G6Pase. Toxicity studies showed that compound 4 is safe as it exerted no toxic effect on any of the hematological and biochemical parameters or on liver histology of the experimental animals at any studied dose rate. The synthesized compounds showed promising antibacterial and antioxidant potential and were very active (both in vitro and in vivo) against G6Pase and moderately active against the other selected enzymes used in this study.