1429045-52-2

Basic information

• Product Name: 1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene
• Synonyms: 1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene
• CAS NO: 1429045-52-2
• Molecular Weight: 414.391
• Mol File: 1429045-52-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene(1429045-52-2)
• EPA Substance Registry System: 1-(((1-phenylcyclohex-3-enyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene(1429045-52-2)

Safety Data

• Hazardous Substances Data: 1429045-52-2(Hazardous Substances Data)

Upstream product

• 1429045-51-1 4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylcyclohexanol 
• 51510-00-0 (8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)methanol 
• 56327-24-3 8-phenyl-1,4-dioxaspiro[4,5]decane-8-carboxaldehyde 
• 51509-98-9 8-Phenyl-1,4-dioxaspiro<4.5>decan-8-carbonitril 
• 25115-74-6 4-cyano-4-phenylcyclohexanone 

Downstream Products

• 1429045-45-3 1-(((1-Phenylcyclohexyl)methoxy)methyl)-3,5-bis(trifluoromethyl)benzene 

Relevant articles and documents

Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression

This report describes the synthesis, structure-activity relationships and activity of piperidine, homopiperidine, and azocane derivatives combining NK1 receptor (NK1R) antagonism and serotonin reuptake transporter (SERT) inhibition. Our studies culminated in the discovery of piperidine 2 and homopiperidine 8 as potent dual NK1R antagonists-SERT inhibitors. Compound 2 demonstrated significant activity in the gerbil forced swimming test, suggesting that dual NK1R antagonists-SERT inhibitors may be useful in treating depression disorders.