142992-99-2

Basic information

• Product Name: 3-NITROPHENYLGUANIDINE NITRATE
• Synonyms: 3-NITROPHENYLGUANIDINE NITRATE;N-(3-Nitrophenyl)guanidine Mononitrate;N-(3-nitro-phenyl)-guanidine
• CAS NO: 142992-99-2
• Molecular Formula: C₇H₈N₄O₂*HNO₃
• Molecular Weight: 243.17686
• Product Categories: Aromatics Compounds;Aromatics;Amines;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 142992-99-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 218-221°C
• Boiling Point: 410.1°C at 760 mmHg
• Flash Point: 201.8°C
• Appearance: /
• Vapor Pressure: 1.85E-07mmHg at 25°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-NITROPHENYLGUANIDINE NITRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITROPHENYLGUANIDINE NITRATE(142992-99-2)
• EPA Substance Registry System: 3-NITROPHENYLGUANIDINE NITRATE(142992-99-2)

Safety Data

• Hazardous Substances Data: 142992-99-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

3-Nitrophenylguanidine Nitrate can be used for the preparation of N-thiazolpyrimidinyl-N-phenylamines as specific cyclin-dependent kinase inhibitors useful as antitumor agents.

InChI:InChI=1/C7H8N4O2.HNO3/c8-7(9)10-5-2-1-3-6(4-5)11(12)13;2-1(3)4/h1-4H,(H4,8,9,10);(H,2,3,4)

Upstream product

• 420-04-2 CYANAMID 
• 33240-96-9 3-nitroaniline hydrochloride 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 136437-10-0 C₁₁H₁₂N₄O₆ 
• 930580-27-1 4-(2-cyclohexyl-4-methyl-1,3-thiazol-5-yl)-N-(3-nitrophenyl)pyrimidine-2-amine 
• 152460-06-5 N-(3-aminophenyl)-4-(pyridin-3-yl)-2-pyrimidine-amine 
• 507487-89-0 [4-(2-amino-4-methyl-thiazol-5-yl)pyrimidin-2-yl]-(3-nitrophenyl)amine 
• 364333-82-4 {4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl}-(3-nitro-phenyl)-amine 
• 152459-85-3 N-(3-nitrophenyl)-4-(pyridin-4-yl)-2-pyrimidine-amine 
• 152459-75-1 N-(3-nitrophenyl)-4-(pyridin-3-yl)-2-pyrimidine-amine 
• 136437-13-3 C₂₃H₂₀N₄O₆ 

Relevant articles and documents

N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof

The present invention relates to an N-phenyl-2-pyrimidine-amine derivative showing a superior effect on lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer, or cervical cancer, etc. of warm-blooded animals and its salt. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various diseases, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.

N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

The present invention relates to an N-Phenyl-2-pyrimidine-aminine derivative showing a superior effect on lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or accute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer or cervical cancer, etc. of warm blooded animals and its salt. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various disease, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.

Anti-cancer compounds

The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders such as cancer, leukaemia, psoriasis and the like.