143-22-6Relevant articles and documents
INHIBITORS OF HEPATITIS C VIRUS POLYMERASE
-
Paragraph 331; 332, (2016/10/11)
The present invention provides, among other things, compounds represented by the general Formula I: (I) and pharmaceutically acceptable salts thereof, wherein L and A (and further substituents) are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
HETEROCYCLIC AMINE CATALYST COMPOSITIONS FOR THE ALKOXYLATION OF ALCOHOLS TO GLYCOL ETHERS
-
Page/Page column 8-9, 11, (2009/12/05)
Glycol ethers are made by a process in which an alcohol, an alkylene oxide and a catalytic amount of an aromatic, heterocyclic amine catalyst are contacted under reactive conditions. Representative catalysis include substituted and unsubsiituted pyridines and imidazoles. The process uses known oxides and alcohols, and produces more mono- and di- adduct products than does a corresponding process using a caustic catalyst. Moreover, the process can be conducted at a lower reaction temperature than a corresponding process using a caustic catalyst without sacrificing oxide conversion rates yet producing fewer carfoony! impurities.
METHOD FOR PRODUCING MONOALKYLENE GLYCOL MONOETHER
-
Page/Page column 24-25, (2010/02/14)
The invention relates to a method for producing monoalkylene glycol monoether of general formulas (Ia) and (Ib), wherein a group R is hydrogen, a methyl-, ethyl-, propyl- or butyl group and R1 is a phenyl or a linear or branched C1-C10 alkyl group consisting in reacting an alcohol R1OH (II) with an alkylene oxide (III) in the presence of a heterogeneous catalyst in a liquid phase which contains in the form of a catalytically active agent at least one composition of formula (IV): M1pAnm x zH2O, wherein M1is hydrogen and/or one or several cations of IA, IIA, IIIA groups, a IVA, IB, IIB, IIIB, IVB, VB, VIB, VIIB or VIIIB lanthanide groups, An is an anion of formula [M2qOn(OH)2(3-n)], wherein M2 is at least one cationic element from a group of pnicogens As, Sb and Bi, the index q is a value equal to 1, the index n is a fractional or an integer number equal to or greater than 0 and strictly less than 3, z is equal to 0 or an integer or fractional number strictly greater than 0 and equal or less than 10, the index p is a value normalised to 1 and the index m is a number ranging from 1.2 to 8 stoichiometrically obtainable from the electric charge of one or several cations M1 and from the electric charge of an An anion taking in to account the index p whose value is normalised to 1 at a temperature ranging from a room temperature to 350 °C, at a pressure ranging from atmospheric pressure to 80 bar and at a molar ratio alcohol II/alkylene oxide III ranging from 3:1 to 15:1.
