143193-44-6

Basic information

• Product Name: 4-butylamino-3-nitrobenzonitrile
• Synonyms: 4-butylamino-3-nitrobenzonitrile
• CAS NO: 143193-44-6
• Molecular Weight: 219.243
• Mol File: 143193-44-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-butylamino-3-nitrobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-butylamino-3-nitrobenzonitrile(143193-44-6)
• EPA Substance Registry System: 4-butylamino-3-nitrobenzonitrile(143193-44-6)

Safety Data

• Hazardous Substances Data: 143193-44-6(Hazardous Substances Data)

Upstream product

• 939-80-0 4-chloro-3-nitrobenzonitrile 
• 109-73-9 N-butylamine 

Downstream Products

• 143173-92-6 3-amino-4-butylaminobenzonitrile 
• 434937-20-9 1-butyl-2-(4-cyanophenyl)-5-cyano-1H-benzimidazole 
• 475490-03-0 5-cyano-2-(4-fluorophenyl)-1-propyl-1H-indole 
• 475490-02-9 1-butyl-2-phenyl-1H-benzoimidazole-5-carbonitrile 

Relevant articles and documents

Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles

(Chemical Equation Presented) A series of 47 novel N1-alkylated- 2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogues 108-110 have no inhibitory activity.

Ring cleavage of dicyano-substituted benzimidazoles by Dibal

Ring cleavage of 1-butyl-2-(4-cyanophenyl)-1H-benzimidazole-5-carbonitrile (5) and 1-benzyl-2-(4-cyanophenyl)-1H-benzimidazole-5-carbonitrile (6) using diisobutylaluminum hydride is reported.