143388-64-1 Usage
Description
Naratriptan Hydrochloride (125 MG)F0C3600.998MG/MG(AI) is a triptan drug used primarily for the treatment of migraine headaches. It is a selective 5-hydroxytryptamine1 (5-HT1) receptor subtype agonist, specifically targeting 5-HT1B and 5-HT1D receptors with modest affinity for 5-HT1A receptors and very weak affinity for 5-HT3 receptors. Naratriptan Hydrochloride has little or no affinity for a wide range of non-serotonin receptors, including alphaand beta-adrenoceptors, dopamine, neurokinin NK1, and opiate receptors. It works by mediating vasoconstriction in cerebral vasculature, reducing neurogenic inflammation, and inhibiting responses mediated by the trigeminal nerves. It is chemically available as a beige solid and has high oral bioavailability.
Uses
1. Used in Pharmaceutical Industry:
Naratriptan Hydrochloride (125 MG)F0C3600.998MG/MG(AI) is used as an active pharmaceutical ingredient for the treatment of migraine headaches. It provides relief by targeting specific serotonin receptors, reducing inflammation and constricting blood vessels in the brain.
2. Used in Migraine Treatment:
Naratriptan Hydrochloride (125 MG)F0C3600.998MG/MG(AI) is used as a migraine treatment to alleviate the symptoms of migraine headaches. It has been found to have a longer duration of action, better tolerability, and less recurrence of headache compared to other triptan drugs like sumatriptan, zolmitriptan, and rizatriptan.
3. Used as a Laxative:
Although not a primary application, Naratriptan Hydrochloride (125 MG)F0C3600.998MG/MG(AI) can also be used as a laxative due to its effects on the gastrointestinal system.
4. Used in Clinical Trials:
Naratriptan Hydrochloride (125 MG)F0C3600.998MG/MG(AI) is used in clinical trials to study its efficacy and safety in treating migraine headaches and to compare its performance with other available treatments.
5. Used in Research and Development:
Naratriptan Hydrochloride (125 MG)F0C3600.998MG/MG(AI) is utilized in research and development for the discovery of new drugs and therapies targeting migraine headaches and other related conditions. Its unique receptor affinity profile makes it a valuable compound for studying the role of serotonin receptors in migraine pathophysiology.
Check Digit Verification of cas no
The CAS Registry Mumber 143388-64-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,3,8 and 8 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 143388-64:
(8*1)+(7*4)+(6*3)+(5*3)+(4*8)+(3*8)+(2*6)+(1*4)=141
141 % 10 = 1
So 143388-64-1 is a valid CAS Registry Number.
InChI:InChI=1/C17H25N3O2S.ClH/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14;/h3-4,11-12,14,18-19H,5-10H2,1-2H3;1H
143388-64-1Relevant articles and documents
A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN
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, (2011/04/13)
The present invention relates to a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4); (b) converting the compound of formula (4) to a compound of formula (5) wherein Z'' is hydrogen or a benzyl group; (c) converting the compound of formula (5) to naratriptan; and (d) optionally converting naratriptan to a salt thereof. The present invention also provides novel compounds (3) and (4) and processes for their preparation.
PROCESS FOR PREPARATION OF NARATRIPTAN HYDROCHLORIDE
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Page/Page column 28, (2009/10/22)
The present invention relates to an improved process for the preparation of N-methyl-3- (1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride of formula (I) having less than 0.15 % area by HPLC of 3-(1-methyl-4-piperidinyl)-1H-indole-5- ethanesulfonamide (1A) and intermediates thereof.
PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES
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Page/Page column 16-17, (2008/12/06)
The present invention relates to a novel process for the preparation of indole derivatives. In particular, present invention relates to the process for preparing naratriptan of formula (I), and its salts using novel intermediates. The present invention also relates to novel synthetic intermediates useful in the preparation of naratriptan hydrochloride.