143426-47-5

Basic information

• Product Name: Ethyl 4-(1H-Pyrazol-1-yl)benzoate
• Synonyms: Ethyl 4-(1H-Pyrazol-1-yl)benzoate;Ethyl 4-(1-Pyrazolyl)benzoate;Benzoic acid,4-(1H-pyrazol-1-yl)-, ethyl ester
• CAS NO: 143426-47-5
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.24
• Mol File: 143426-47-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 333.2°C at 760 mmHg
• Flash Point: 155.3°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 0.000139mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 4-(1H-Pyrazol-1-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-(1H-Pyrazol-1-yl)benzoate(143426-47-5)
• EPA Substance Registry System: Ethyl 4-(1H-Pyrazol-1-yl)benzoate(143426-47-5)

Safety Data

• Hazardous Substances Data: 143426-47-5(Hazardous Substances Data)

Usage

General Description

Ethyl 4-(1H-Pyrazol-1-yl)benzoate is a chemical compound with the molecular formula C13H12N2O2. It is a derivative of pyrazole, a five-membered heterocyclic compound containing a nitrogen atom. Ethyl 4-(1H-Pyrazol-1-yl)benzoate is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has been reported to exhibit various biological activities, including anti-inflammatory, analgesic, and antifungal properties. The ethyl ester group in the compound makes it suitable for use as a flavoring agent or fragrance in cosmetics and personal care products. Additionally, it has been studied for its potential applications in the development of new drugs.

InChI:InChI=1/C12H12N2O2/c1-2-16-12(15)10-4-6-11(7-5-10)14-9-3-8-13-14/h3-9H,2H2,1H3

Upstream product

• 16209-00-0 4-(1H-pyrazol-1-yl)benzoic acid 
• 64-17-5 ethanol 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 99662-34-7 4-(1H-pyrazol-1-yl)benzaldehyde 
• 288-13-1 NH-pyrazole 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 

Downstream Products

• 1436430-02-2 diethyl 2-(5-(ethoxycarbonyl)-2-(1H-pyrazol-1-yl)phenyl)malonate 

Relevant articles and documents

C?N Cross-Coupling Reactions Under Mild Conditions Using Singlet Di-Radical Nickel(II)-Complexes as Catalyst: N-Arylation and Quinazoline Synthesis

Herein we report a cost-effective synthetic approach for C?N cross-coupling reactions of a broad array of nitrogen nucleophiles and aryl halides under mild conditions. These reactions are catalyzed by an inexpensive, air-stable, earth-abundant and easy-to-prepare singlet di-radical nickel(II)-catalyst containing two antiferromagnetically coupled single-electron oxidized diiminosemiquinonato type ligands. This protocol provides an alternative method for C?N cross-coupling reactions avoiding nickel(0)/nickel(II) or nickel(I)/nickel(III) redox processes via cooperative participation of metal and ligand-centered redox events. Besides a wide range of N-arylation reactions, by judicious choice of aryl halides and nitrogen nucleophiles the synthesis of a variety of polysubstituted quinazolines has been achieved in moderate to good yields under relatively mild reaction conditions. Our catalyst has been found to be almost equally effective in quinazoline synthesis via C?N cross-coupling of (i) 2-bromobenzylamine with benzamide, and (ii) 2-bromobenzylbromide with amidine. Control experiments and DFT studies were performed to improve the understanding of the cooperative participation of ligand and metal (nickel)-centered redox events during oxidative addition/reductive elimination processes of the catalytic cycle and to shed light on the plausible mechanistic pathway of the C?N cross-coupling reactions. (Figure presented.).

HIGH-SENSITIVITY NEAR-INFRARED PHOSPHORESCENT IRIDIUM COMPLEX FOR MEASURING OXYGEN CONCENTRATION IN CELL/TISSUE

PROBLEM TO BE SOLVED: To provide a compound with a long phosphorescence lifetime which can efficiently measure the oxygen concentration in a cell, tissue or the like. SOLUTION: The oxygen concentration is measured using a compound represented by the gener

Selective androgen receptor modulators

This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, and or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, Ie, and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of formulas I, Ia, Ib, Ic, Id, Ie, and intermediates useful in the preparation of same.