1435-44-5

Basic information

• Product Name: 1-CHLORO-2,4-DIFLUOROBENZENE
• Synonyms: 1-CHLORO-2,4-DIFLUOROBENZENE;2,4-DIFLUOROCHLOROBENZENE;1-Chloro-2,4-difluorobenzene 98%;1-Chloro-2,4-difluorobenzene98%;2,4-Diflurochlorobenzene;2,4-Difluorchlorbenzol;1-CHLORO-2,4-DIFLUOROBENZENE / 2,4-DIFLUOROCHLOROBENZENE;2,4-Difluorophenyl chloride
• CAS NO: 1435-44-5
• Molecular Formula: C6H3ClF2
• Molecular Weight: 148.54
• EINECS: -0
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Chlorine Compounds;Fluorine Compounds;Aryl;C6;Halogenated Hydrocarbons;Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorine series
• Mol File: 1435-44-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: -26 °C
• Boiling Point: 127 °C(lit.)
• Flash Point: 91 °F
• Appearance: Clear colourless to light yellow liquid
• Density: 1.353 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.475(lit.)
• Storage Temp.: Flammables area
• BRN: 2081077
• CAS DataBase Reference: 1-CHLORO-2,4-DIFLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-2,4-DIFLUOROBENZENE(1435-44-5)
• EPA Substance Registry System: 1-CHLORO-2,4-DIFLUOROBENZENE(1435-44-5)

Safety Data

• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 2
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 1435-44-5(Hazardous Substances Data)

Usage

Description

1-Chloro-2,4-difluorobenzene is an organic compound with the chemical formula C6H3ClF2. It is a clear, colorless to light yellow liquid at room temperature and is characterized by the presence of a chlorine atom and two fluorine atoms attached to a benzene ring.

Uses

1. Used in the Chemical Industry:
1-Chloro-2,4-difluorobenzene is used as a starting material for the synthesis of various organic compounds, such as benzonorbornadienes and difluoroarenes. Its unique structure and functional groups make it a valuable intermediate in the production of specialty chemicals and pharmaceuticals.
2. Used in the Pharmaceutical Industry:
1-Chloro-2,4-difluorobenzene serves as a key building block in the development of new drugs and pharmaceutical compounds. Its chemical properties allow for further functionalization and modification, leading to the creation of novel molecules with potential therapeutic applications.
3. Used in the Material Science Industry:
1-Chloro-2,4-difluorobenzene can be utilized in the development of advanced materials, such as polymers and coatings, due to its reactive functional groups and compatibility with various polymerization techniques. Its incorporation into these materials can enhance their properties, such as chemical resistance, thermal stability, and mechanical strength.

InChI:InChI=1/C6H3ClF2/c7-5-2-1-4(8)3-6(5)9/h1-3H

Upstream product

• 90802-25-8 2,4-Difluor-benzoldiazonium-chlorid 
• 108-90-7 chlorobenzene 
• 1031226-45-5 (3-chloro-2,6-difluorophenyl)boronic acid 
• 372-18-9 1,3-Difluorobenzene 
• 225104-76-7 2,6-difluoro-3-chlorobenzoic acid 
• 38361-37-4 1-chloro-2,6-difluorobenzene 
• 75-05-8 acetonitrile 
• 26120-88-7 2,4-dichlorobenzenesulfonyl fluoride 

Downstream Products

• 36556-37-3 1,3-dichloro-2,4-difluorobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 107-14-2 chloroacetonitrile 
• 3939-09-1 2,4-difluorobenzonitrile 
• 501-29-1 1-chloro-2-fluoro-4-methoxybenzene 
• 450-89-5 1-chloro-4-fluoro-2-methoxybenzene 
• 225104-76-7 2,6-difluoro-3-chlorobenzoic acid 
• 773873-97-5 methyl 3-chloro-2,6-difluorobenzoate 
• 1225031-06-0 1-(2,4-difluorobenzyl)-4-methylbenzene 
• 86386-73-4 fluconazole 

Relevant articles and documents

Reactions of aromatic compounds with xenon difluoride

Reactions of substituted benzenes C6H5R (R = Me, F, Cl, Br, CF3, NO2) with xenon difluoride in the presence of boron trifluoride–diethyl ether complex in weakly acidic (1,1,1,3,3-pentafluorobutane) and weakly basic media (acetonitrile) have been studied. These reactions lead to the formation of fluorobenzene derivatives FC6H4R (isomer mixture) together with isomeric difluorobenzenes and fluorinated and non-fluorinated biphenyls. The results have been compared with previously reported data obtained in other solvents using other catalysts.

Efficient oxidative chlorination of aromatics on saturated sodium chloride solution

An efficient metal-free system using saturated aqueous sodium chloride/aqueous ammonium chloride solution as chlorine source and potassium persulfate as a cheap oxidant for the chlorination of various aromatic compounds including deactivated ones has been developed that proceeds without any acid additive in an excellent regioselective manner. The easy-to-handle aqueous solution/acetonitrile biphasic system as solvent and no need for precautionary measures make this process very practical. Copyright

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.