143653-53-6
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Basic information
- Product Name: abciximab
- Synonyms: Reopro;Unii-X85G7936gv;CentoRx;Immunoglobulin G1, (human-mouse monoclonal c7E3 clone p7E3VHhCgamma1 Fab fragment anti-human glycoprotein IIb/IIIa receptor), disulfide with human-mouse monoclonal c7E3 clone p7E3VkappahCkappa light chain;Rheopro
- CAS NO:143653-53-6
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
- Mol File: 143653-53-6.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: abciximab(CAS DataBase Reference)
- NIST Chemistry Reference: abciximab(143653-53-6)
- EPA Substance Registry System: abciximab(143653-53-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 143653-53-6(Hazardous Substances Data)
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143653-53-6 Usage
Uses
Monoclonal antibody (antithrombotic).Brand name
ReoPro (Lilly).Clinical Use
Antiplatelet agent: Prevention of ischaemic cardiac complications in patients undergoing percutaneous coronary intervention Short-term prevention of myocardial infarction in patients with unstable angina not responding to treatment or awaiting percutaneous coronary intervention.Enzyme inhibitor
This antithrombotic (MW = 47455 g/mol; CAS 143653-53-6; also known as Reopro?) consists of an immunoglobulin G1 Fab fragment from a chimeric human-murine monoclonal antibody directed against the human platelet glycoprotein IIb/IIIa receptor. Abciximab also facilitates the dispersal of newly formed platelet aggregates in vitro, by partially displacing fibrinogen from activated GPIIb/IIIareceptors. In vivo, abciximab may destabilize coronary thrombi by preventing aggregate formation and dispersing mural thrombi. Target(s): coagulation factor Xa, in presence of heparin; glycoprotein IIb/IIIa receptor.Drug interactions
Potentially hazardous interactions with other drugs Heparin, anticoagulants, antiplatelets and thrombolytics: increased risk of bleeding.Metabolism
Following IV administration, abciximab rapidly binds to the platelet GPIIb/IIIa receptors, and remains in the circulation for 15 days or more in a platelet-bound state. Metabolism is via proteolytic cleavageCheck Digit Verification of cas no
The CAS Registry Mumber 143653-53-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,6,5 and 3 respectively; the second part has 2 digits, 5 and 3 respectively.Calculate Digit Verification of CAS Registry Number 143653-53:
(8*1)+(7*4)+(6*3)+(5*6)+(4*5)+(3*3)+(2*5)+(1*3)=126
126 % 10 = 6
So 143653-53-6 is a valid CAS Registry Number.
143653-53-6Upstream product
143653-53-6Downstream Products
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abciximab
