143673-42-1Relevant articles and documents
Synthesis of tetraketones in water and under catalyst-free conditions
Yu, Jian-Jun,Wang, Li-Min,Liu, Jin-Qian,Guo, Feng-Lou,Liu, Ying,Jiao, Ning
, p. 216 - 219 (2010)
A simple, environmentally friendly, tandem Knoevenagel condensation and Michael addition procedure is reported. The reactions between cyclic-13-diketones and a variety of aldehydes were carried out in water to afford tetraketones (64-99%). In this green synthetic protocol, the solvent water itself catalysed the reaction by hydrogen bonding, thus avoiding the use of any other catalysts to make the work up procedure easier.