14377-18-5

Basic information

• Product Name: 1-(4-methylphenyl)prop-2-yn-1-one
• Synonyms: 1-(4-methylphenyl)prop-2-yn-1-one
• CAS NO: 14377-18-5
• Molecular Weight: 144.173
• Mol File: 14377-18-5.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 1-(4-methylphenyl)prop-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)prop-2-yn-1-one(14377-18-5)
• EPA Substance Registry System: 1-(4-methylphenyl)prop-2-yn-1-one(14377-18-5)

Safety Data

• Hazardous Substances Data: 14377-18-5(Hazardous Substances Data)

Usage

General Description

1-(4-methylphenyl)prop-2-yn-1-one, also known as p-methylphenylpropiophenone, is a chemical compound with the molecular formula C10H10O. It is an aryl alkynone that contains a prop-2-yn-1-one functional group and a 4-methylphenyl substituent. 1-(4-methylphenyl)prop-2-yn-1-one is commonly used in organic synthesis and pharmaceutical research as a precursor for the synthesis of various pharmaceuticals and other organic compounds. It is also known for its potential pharmacological properties, although further research is needed to fully understand its biological activities. Additionally, this chemical has applications in the field of material science, particularly in the development of novel polymeric materials and coatings.

Upstream product

• 37166-45-3 1-(4''methylphenyl)-3-(trimethylsilyl)prop-2-ynone 
• 910219-57-7 1-(4-methylphenyl)-3-(trimethylsilyl)-2-propyn-1-ol 
• 104-87-0 4-methyl-benzaldehyde 
• 132589-36-7 1-(4-methylphenyl)prop-2-yn-1-ol 

Downstream Products

• 59843-75-3 3-p-tolyl-1H-pyrazole 
• 1142923-50-9 C₂₂H₂₃NO₃ 
• 1142923-59-8 C₂₃H₂₅NO₃ 
• 1338721-52-0 1-methyl-N-((E)-3-oxo-3-p-tolylprop-1-enyl)-N-phenyl-1H-imidazole-2-carboxamide 
• 1411840-88-4 C₂₀H₁₆O₂ 
• 25305-41-3 benzene-1,3,5-triyltris(p-tolylmethanone) 
• 122-00-9 para-methylacetophenone 
• 1412898-46-4 5-benzoyl-1,3-di(p-toluoyl)benzene 
• 98-86-2 acetophenone 
• 34740-23-3 2-methyl-5-(p-methylphenyl)furan 
• 108362-06-7 2-ethyl-5-(p-tolyl)furan 
• 17113-32-5 2-(4-methylphenyl)furan 

Relevant articles and documents

Calcium phosphate-vanadate apatite (CPVAP)-catalyzed aerobic oxidation of propargylic alcohols with molecular oxygen

Calcium phosphate-vanadate apatite (CPVAP) works effectively as a catalyst for the aerobic oxidation of propargylic alcohols to the corresponding carbonyl compounds under an atmospheric pressure of molecular oxygen. Moreover, CPVAP can be readily separated by filtration and reused at least 10 times without appreciable loss of the catalytic activity.

Multisubstituted pyrazole synthesis via [3?+?2] cycloaddition/rearrangement/N[sbnd]H insertion cascade reaction of α-diazoesters and ynones

The cascade reactions of alkyl α-diazoesters and ynones using Al(OTf)3 as the catalyst are described. A series of 4-substituted pyrazoles were obtained via [3 + 2] cycloaddition, 1,5-ester shift, 1,3-H shift, and N[sbnd]H insertion process. Deuterium labelling experiments, kinetic studies and control experiments were carried out for the rationalization of the mechanism.

Enantioselective [3 + 2] annulation of 4-isothiocyanato pyrazolones and alkynyl ketones under organocatalysis

An asymmetric [3 + 2] annulation reaction of 4-isothiocyanato pyrazolones with alkynyl ketones in the presence of an organic catalyst derived from a cinchona alkaloid under mild conditions is realized. This protocol provides unprecedented expeditious access to a wide range of optically active spiro[pyrroline-pyrazolones] with various electronic properties in high yields with good to excellent enantioselectivities.

A sustainable access to ynones through laccase/TEMPO-catalyzed metal- and halogen-free aerobic oxidation of propargylic alcohols in aqueous medium

Tuning laccase/TEMPO-catalyzed aerobic oxidation of secondary propargylic alcohols in aqueous media was accomplished in order to efficiently synthesize ynones. This study led to the formulation of an effective and sustainable catalytic method for the preparation of mono- and bis-substituted ynones compared with traditional oxidative methods.