143839-02-5

Basic information

• Product Name: 2,24-Dihydroxyursolic acid
• Synonyms: 2,24-Dihydroxyursolic acid
• CAS NO: 143839-02-5
• Molecular Formula: C₃₀H₄₈O₅
• Molecular Weight: 488.7
• Mol File: 143839-02-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,24-Dihydroxyursolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,24-Dihydroxyursolic acid(143839-02-5)
• EPA Substance Registry System: 2,24-Dihydroxyursolic acid(143839-02-5)

Safety Data

• Hazardous Substances Data: 143839-02-5(Hazardous Substances Data)

Usage

General Description

2,24-Dihydroxyursolic acid is a chemical compound that belongs to the class of organic compounds known as triterpenoids. It is derived from ursolic acid, a type of pentacyclic triterpenoid. As its name suggests, it is characterised by two hydroxyl groups on the 2nd and 24th carbons of the ursolic acid molecule. It's known for its various biological activities such as antioxidant, anti-inflammatory, and antitumor properties. Its applications are mainly found in the fields of medicine and pharmacology. However, further research is needed to fully understand its potential benefits and effects.

Upstream product

• 16830-15-2 asiaticoside 

Downstream Products

• 20016-63-1 methyl 2α,3β,23-trihydroxyurs-12-en-28-oate 
• 19533-98-3 methyl 2α-hydroxy-3β,23-isopropylidenedioxyurs-12-ene-28-oate 
• 1575689-22-3 methyl 2α-O-(N-fluorenonemethyoxycarbonyl)-phenyglycylurs-3β,23-isopropylidenedioxyurs-12-ene-28-oate 
• 1575689-23-4 methyl 2-O-phenyglycylurs-3,23-isopropylidenedioxyurs-12-ene-28-oate 
• 57498-76-7 (2α,3β)-2,3-bis(acetyloxy)-urs-12-en-28-oic acid 

Relevant articles and documents

Method for preparing asiatic acid by hydrolyzing asiaticoside

The invention discloses a method for preparing asiatic acid by hydrolyzing asiaticoside. The method comprises the following steps: 1) mixing asiaticoside, lauryl sodium sulfate and NaOH, adding water for dissolution, and hydrolyzing at normal temperature for 10-15 minutes; 2) regulating the pH value of the hydrolysate to 2-5, standing, filtering, and collecting the precipitate; and 3) dissolving the precipitate in ethanol, filtering, adding water to the filtrate, crystallizing, filtering to obtain the crystal, and drying to obtain the finished product. The method can quickly cut off glycosidic bonds under the conditions of normal temperature and pressure, has the advantages of mild hydrolytic process and thorough hydrolysis, and can not generate configurative changes of asiatic acid.

An Asiatic acid derivatives

The invention provides derivatives based on an asiatic acid structure for modification. Pharmacological activity experiments prove that the compounds provided by the invention (in particular to 5a, 5b, 5d and 5f) have relatively good antifibrotic activity; and furthermore, in comparison with asiatic acid, the compounds disclosed by the invention have the advantages that the lipid solubility is improved, and new choices are provided for clinical medicines.

Design, synthesis, and biofunctional evaluation of novel pentacyclic triterpenes bearing O-[4-(1-piperazinyl)-4-oxo-butyryl moiety as antiproliferative agents

A series of pentacyclic triterpenoids derivatives bearing O-[4-(1-piperazinyl)-4-oxo-butyryl moiety has been synthesized and investigated for their potential antiproliferative activities. Pentacyclic triterpenoids derivative compounds were synthesized by a four or six step synthetic procedure. The activity studies were evaluated using Cell Counting Kit-8 method, and Western blotting analysis on A549 cells, MCF-7 cells and Hela cells. Compounds methyl 3-O-[4-(1-piperazinyl)-4-oxo-butyryl]olean-12-ene-28-oate (OA-4) and compound 2-O-[4-(1-piperazinyl)-4-oxo-butyryl]-3,23-dihydroxyurs-12-ene-28-oate (AA-5) were found to be promising antiproliferative agents. These compounds show potentiality for further optimization as antitumor drugs.