14389-77-6

Basic information

• Product Name: (S)-3-Aminopentanoic acid
• Synonyms: (s)-3-amino-valeric acid;(S)-3-Aminopentanoic acid;REF DUPL: S-3-amino-valeric acid;Pentanoic acid, 3-amino-, (3S)-
• CAS NO: 14389-77-6
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.15
• Product Categories: API intermediates
• Mol File: 14389-77-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 230.1 °C at 760 mmHg
• Flash Point: 93 °C
• Appearance: Colorless to pale yellow liquid
• Density: 1.067 g/cm³
• Vapor Pressure: 0.0238mmHg at 25°C
• Refractive Index: 1.463
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: (S)-3-Aminopentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Aminopentanoic acid(14389-77-6)
• EPA Substance Registry System: (S)-3-Aminopentanoic acid(14389-77-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 14389-77-6(Hazardous Substances Data)

Usage

Purification Methods

Crystallise the amino acid from EtOH/Et2O. [Beilstein 4 II 843, 4 III 1342, 4 IV 2635.]

InChI:InChI=1/C5H11NO2/c1-2-4(6)3-5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

Upstream product

• 15790-87-1 Methyl (E)-2-pentenoate 
• 78221-21-3 3-aminopentanoic acid ethyl ester 
• 343335-40-0 ethyl (S)-3-acetamidopentanoate 

Downstream Products

• 1086106-57-1 (S)-3-amino-pentanoic acid methyl ester 
• 1236525-13-5 methyl (3S)-3-aminopentanoate hydrochloride 
• 1086106-60-6 6-(S)-ethyl-1-(4-fluoro-benzyl)-4-hydroxy-3-(1-methyl-7-nitro-1-oxo-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5,6-dihydro-1H-pyridin-2-one 
• 1086106-61-7 3-(7-amino-1-methyl-1-oxo-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-6-(S)-ethyl-1-(4-fluoro-benzyl)-4-hydroxy-5,6-dihydro-1H-pyridin-2-one 
• 1086106-58-2 (S)-3-(4-fluoro-benzylamino)-pentanoic acid methyl ester 
• 1381761-92-7 (S)-1-(4-(tert-butyl)phenyl)-3-(1-oxopentan-3-yl)urea 
• 1381761-93-8 1-((S)-1-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea 
• 1381761-91-6 (S)-1-(4-(tert-butyl)phenyl)-3-(1-hydroxypentan-3-yl)urea 
• 1381761-90-5 (S)-methyl 3-(3-(4-(tert-butyl)phenyl)ureido)pentanoate 
• 1381761-94-9 1-((S)-1-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)amino)pentan-3-yl)-3-(4-(tert-butyl)phenyl)urea 
• 1181218-09-6 (S)-methyl 2-[(S)-(1-benzyloxycarbonylamino)propyl]octanoate 
• 1181218-10-9 methyl (S)-3-(benzyloxycarbonylamino)pentanoate 

Relevant articles and documents

Preparation of highly enantiopure β-amino esters by Candida antarctica lipase A

The enantioselectivities for the reactions of aliphatic β-substituted β-amino esters [RCH(NH2)CH2CO2Et with R = Me, Et, n-Pr, i-Pr, CHEt2, cyclohexyl and Ph] with butyl butanoate in neat butyl butanoate and with 2,2,2-trifluoroethyl butanoate in diisopropyl ether were studied in the presence of Candida antarctica lipase A. Enantioselectivities ranging from good (E = 70-100) to excellent (E>100) were commonly observed, allowing gram-scale resolution of the substrates.

Enantioselektive Synthese von β-Aminosaeuren - TMS-SAMP als chirales Ammoniak-Aequivalent in der azaanalogen Michael-Addition an α,β-ungesaettigte Ester

Stichworte: Aminosaeuren * Asymmetrische Synthesen * Chirale Hilfsstoffe * Michael-Additionen